Mesoporous silica nanocarriers encapsulated antimalarials with high therapeutic performance

dc.creatorAmolegbe, Saliu Alao
dc.creatorHirano, Yui
dc.creatorAdebayo, Joseph Oluwatope
dc.creatorAdemowo, Olusegun George
dc.creatorBalogun, Elizabeth Abidemi
dc.creatorObaleye, Joshua Ayoola
dc.creatorKrettli, Antoniana Ursine
dc.creatorYu, Chengzhong
dc.creatorHayami, Shinya
dc.date2019-06-19T18:25:04Z
dc.date2019-06-19T18:25:04Z
dc.date2018
dc.date.accessioned2023-09-26T20:08:31Z
dc.date.available2023-09-26T20:08:31Z
dc.identifierAMOLEGBE, Saliu Alao et al. Mesoporous silica nanocarriers encapsulated antimalarials with high therapeutic performance. Scientific Reports, v. 8, 3078, 2018
dc.identifier2045-2322
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/33598
dc.identifier10.1038/s41598-018-21351-8
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8849544
dc.descriptionThe use of nanocarriers in drug delivery is a breakeven research and has received a clarion call in biomedicine globally. Herein, two newly nano-biomaterials: MCM-41 encapsulated quinine (MCM-41 ⊃ QN) (1) and 3-phenylpropyl silane functionalized MCM-41 loaded QN (pMCM-41 ⊃ QN) (2) were synthesized and well characterized. 1 and 2 along with our two already reported nano-antimalarial drugs (MCM-41 ⊃ ATS) (3) and 3-aminopropyl silane functionalized MCM-41 contained ATS (aMCM-41 ⊃ ATS) (4) were screened in vitro for their activity against P. falciparium W2 strain, cytotoxicity against BGM cells and in vivo for their activity against Plasmodium bergheiNK65. 1 has the highest antimalarial activity in vivo against P. berghei NK65, (ED50: < 0.0625 mg/kg body weight) and higher mean survival time compared to the other nano biomaterials or unencapsulated drugs at doses higher than 0.0625 mg/kg body weight. This encapsulation strategy of MCM-41 ⊃ QN (1) stands very useful and effective in delivering the drug to the target cells compared to other delivery systems and therefore, this encapsulated drug may be considered for rational drug design.
dc.description2022-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherNature Research
dc.rightsrestricted access
dc.subjectMalaria
dc.subjectPlasmodium
dc.subjectMalaria
dc.subjectPlasmodium
dc.subjectnano-antimalaria drugs
dc.titleMesoporous silica nanocarriers encapsulated antimalarials with high therapeutic performance
dc.typeArticle


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