Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation

dc.creatorBarbosa, Victor Augusto Araújo
dc.creatorLery, Leticia Miranda Santos
dc.date2019-09-05T13:54:46Z
dc.date2019-09-05T13:54:46Z
dc.date2019
dc.date.accessioned2023-09-26T20:08:30Z
dc.date.available2023-09-26T20:08:30Z
dc.identifierBARBOSA, Victor Augusto Araújo; LEVY, Leticia Miranda Santos. Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation. BMC Genomics, v. 20, n. 506, p. 1-12, 2019.
dc.identifier1471-2164
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/35352
dc.identifier10.1186/s12864-019-5885-9
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8849539
dc.descriptionKlebsiella pneumoniae (KP) is an opportunistic pathogen that mainly causes respiratory and urinary tract infections. The frequent occurrence of simultaneously virulent and multiple drug-resistant isolates led WHO to include this species in the list of top priorities for research and development of therapeutic alternatives. The comprehensive knowledge of the molecular mechanisms underlying KP virulence may lead to the proposal of more efficient and specific drugs. One of its virulence factors is the Type VI Secretion System (T6SS), which contributes to bacterial competition, cell invasion and in vivo colonisation. Despite the few studies showing the involvement of T6SS in KP pathogenesis, little is known concerning the regulation of its expression. The understanding of regulatory mechanisms may give more clues about the function of the system and the possibilities of future interference in this process. This work aimed to standardise the annotation of T6SS genes in KP strains and identify mechanisms of their transcriptional regulation through computational predictions.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBMC
dc.rightsopen access
dc.subjectKlebsiella pneumoniae
dc.subjectSistema de secreção tipo VI
dc.subjectRegulador transcricional
dc.subjectAnálise do genoma bacteriano
dc.subjectType VI secretion system
dc.subjectT6SS
dc.subjectKlebsiella pneumoniae
dc.subjectTranscriptional regulator
dc.subjectBacterial genome analysis
dc.titleInsights into Klebsiella pneumoniae type VI secretion system transcriptional regulation
dc.typeArticle


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