Homology Inference Based on a Reconciliation Approach for the Comparative Genomics of Protozoa

dc.creatorCampos, Darueck A.
dc.creatorPereira, Elisa C.
dc.creatorJardim, Rodrigo
dc.creatorCuadrat, Rafael R. C.
dc.creatorBernardes, Juliana S.
dc.creatorDávila, Alberto M. R.
dc.date2018-10-11T14:49:38Z
dc.date2018-10-11T14:49:38Z
dc.date2018
dc.date.accessioned2023-09-26T20:08:29Z
dc.date.available2023-09-26T20:08:29Z
dc.identifierCAMPOS, Darueck A. et al. Homology Inference Based on a Reconciliation Approach for the Comparative Genomics of Protozoa. Evolutionary Bioinformatics, v.14, n.1-2, 12p, 2018.
dc.identifier1176-9343
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/29521
dc.identifier10.1177/1176934318785138
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8849527
dc.descriptionProtozoa parasites are responsible for several diseases in tropical countries, such as malaria, sleeping sickness, Chagas disease, leishmaniasis, amebiasis, and giardiasis, which together threaten millions of people around the world. In addition, most of the classic parasitic diseases due to protozoa are zoonotic. Understanding the biology of these organisms plays a relevant role in combating these diseases. Using homology inference and comparative genomics, this study targeted 3 protozoan species from different Phyla: Cryptosporidium muris (Apicomplexa), Entamoeba invadens (Amoebozoa), and Trypanosoma grayi (Euglenozoa). In this study, we propose a new approach for the identification of homologs, based on the reconciliation of the results of 2 different homology inference software programs. Our results showed that 46.1% (59/128) of the groups inferred by our reconciliation approach could be validated using this methodology. These validated groups are here called homologous Supergroups and were compared with SUPERFAMILY and Pfam Clans.
dc.formatapplication/pdf
dc.languageeng
dc.publisherLibertas Academica
dc.rightsopen access
dc.subjectHomologia
dc.subjectParasitas
dc.subjectdomínios conservados
dc.subjectreconciliação
dc.subjectprotozoa
dc.subjecthomology
dc.subjectconserved domains
dc.subjectreconciliation
dc.subjectdistant homology
dc.titleHomology Inference Based on a Reconciliation Approach for the Comparative Genomics of Protozoa
dc.typeArticle


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