Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study

dc.creatorAndrade, Sonia Gumes
dc.creatorSilva, R. C.
dc.creatorSantiago, Christiane Maria Gaspar
dc.creatorFreitas, Luiz Antonio Rodrigues de
dc.date2014-07-10T18:15:19Z
dc.date2014-07-10T18:15:19Z
dc.date1987
dc.date.accessioned2023-09-26T20:08:03Z
dc.date.available2023-09-26T20:08:03Z
dc.identifierANDRADE, S. G. et al. Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study. Bulletin of the World Health Organization, v. 65, n. 5, p. 625-633, 1987.
dc.identifier0042-9686
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7912
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8849332
dc.descriptionThe anti-protozoal drug MK-436 (3-(J-methyl-5-nitroimidazol-2-yl)-3a,4,5,6,7,7ahexahydro-1,2-benzisoxazole) was found to be effective against Trypanosoma cruzi infections in mice (2 daily doses of250 mg per kg body weight). Parasitaemia disappeared within 24 hours oftreatment which was commenced during the early or late stages ofacute infection. Intracellular T. cruzi parasites were also affected by the drug, ultrastructural findings showing severe cytoplasmic vacuolization and membrane alterations. Positive serological responses persisted in the majority oftreated and parasitologically cured mice in the study. Cure rates varied from 72% to 100% and were similar regardless of the T. cruzi strain used (Y strain, type 1; 12 SF strain, type II; or Colombian strain, type III). However, the proportion ofpositive serological tests and the frequency of inflammatory lesions were greatestfor mice that were infected with the Colombian strain ofthe parasite.
dc.formatapplication/pdf
dc.languageeng
dc.publisherWorld Health Organization
dc.rightsopen access
dc.subjectDoença de Chagas/quimioterapia
dc.subjectModelos Animais de Doenças
dc.subjectNitroimidazóis/uso terapêutico
dc.subjectTripanossomicidas/uso terapêutico
dc.subjectAnimais
dc.subjectCardiomiopatia Chagásica/parasitologia
dc.subjectCardiomiopatia Chagásica/patologia
dc.subjectDoença de Chagas/parasitologia
dc.subjectDoença de Chagas/patologia
dc.subjectFeminino
dc.subjectMasculino
dc.subjectCamundongos
dc.subjectMiocárdio/ultraestrutura
dc.subjectTripanossomicidas/farmacologia
dc.subjectTrypanosoma cruzi/efeitos de drogas
dc.subjectTrypanosoma cruzi/ultraestrutura
dc.titleTherapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study
dc.typeArticle


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