Experimental leptospirosis in marmoset monkeys (Callithrix jacchus): a new model for studies of severe pulmonary leptospirosis

dc.creatorPereira, Martha Maria
dc.creatorSilva, João José Pereira da
dc.creatorPinto, Marcelo Alves
dc.creatorSilva, Mauro França da
dc.creatorMachado, Marcelo Pelajo
dc.creatorLenzi, Henrique Leonel
dc.creatorMarchevsky, Renato Sergio
dc.date2012-02-28T14:15:30Z
dc.date2012-02-28T14:15:30Z
dc.date2005
dc.date.accessioned2023-09-26T20:07:53Z
dc.date.available2023-09-26T20:07:53Z
dc.identifierPEREIRA, M. M. et al. Experimental leptospirosis in marmoset monkeys (Callithrix jacchus): a new model for studies of severe pulmonary leptospirosis. American Journal of Tropical Medicine and Hygiene, v.72, n.1, p. 13-20, 2005.
dc.identifier0002-9637
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/3783
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8849261
dc.descriptionAcknowledgments: We thank Antonio José Alves, Emilson Domingues da Silva, José Mariano da Silva, José Wanderley Pissurno, and Luzia de Fatima Caputo for their excellent and dedicated technical support. We also thank the Primate Information Center, University of Washington (Seattle, WA) for providing bibliographic information about leptospirosis in primates.
dc.descriptionFinancial support: This study was supported by grants from the National Council for Scientific and Technological Development–CNPq, Brazil.
dc.descriptionExperimental infection of marmoset monkeys (Callithrix jacchus) with Leptospira interrogans serovar Copenhageni showed microscopic patterns of tissue reactions comparable to those seen in the severe forms of human leptospirosis, including intra-alveolar hemorrhage. The most impressive microscopic changes were seen in the lung and kidney of animals killed at days 6 and 12 after inoculation. There were extensive and irregular areas of hemorrhage predominating around main bronchial branches or diffusely spread to the pulmonary parenchyma, as well as severe tubulointerstitial nephritis. Antibody response detected by the microscopic agglutination test was quantitatively similar to those seen in humans and paralleled severity of tissue lesions. The distribution of leptospires or antigenic debris in infected tissues was observed by immunofluorescence and confocal laser scanning microscopy. Large numbers of typical leptospires were seen in the lumen of proximal renal tubules. Positive reactions showing antigenic debris were closely associated with sites of tissue damage.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.rightsopen access
dc.subjectHemorrhage
dc.subjectEtiology
dc.subjectLeptospirosis
dc.subjectImmunology
dc.subjectPathology
dc.subjectAnimals
dc.subjectHaplorhini
dc.subjectHaplorrinos
dc.subjectAnimais
dc.subjectHemorragia
dc.subjectLeptospirose
dc.subjectImunologia
dc.subjectPatologia
dc.subjectEtiologia
dc.titleExperimental leptospirosis in marmoset monkeys (Callithrix jacchus): a new model for studies of severe pulmonary leptospirosis
dc.typeArticle


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