Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy.

dc.creatorSoares, Milena Botelho Pereira
dc.creatorMacambira, Simone Garcia
dc.creatorCarvalho, Antonio Carlos Campos de
dc.creatorSantos, Ricardo Ribeiro dos
dc.date2015-04-17T17:22:31Z
dc.date2015-04-17T17:22:31Z
dc.date2007
dc.date.accessioned2023-09-26T20:07:18Z
dc.date.available2023-09-26T20:07:18Z
dc.identifierSOARES, M. B. P. et al. Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy. Regenerative Medicine, v. 2, n. 3, p. 257-264, 2007.
dc.identifier1746-076X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/10078
dc.identifier10.2217/17460751.2.3.257
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8848984
dc.descriptionNearly a century after its discovery, Chagas' disease, caused by the protozoan Trypanosoma cruzi, remains a major health problem in Latin America. Although efforts in transmission control have contributed to a decrease in the number of new cases, approximately a third of chronic Chagasic individuals have or will develop the symptomatic forms of the disease, mainly cardiomyopathy. Chagas' disease is a progressively debilitating disease, which, at the final stages, there are no currently available treatments other than heart transplantation. In this scenario, cellular therapy is being tested as an alternative for millions of patients with heart dysfunction due to Chagas' disease. In this article, we review the studies of cellular therapy in animal models and in patients with Chagasic cardiomyopathy and the possible mechanisms by which cellular therapy may act in this disease.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFuture Medicine
dc.rightsopen access
dc.subjectCardiomyopathy
dc.subjectCellular therapy
dc.subjectChagas disease
dc.subjectFibrosis
dc.subjectInflammation
dc.subjectStem cells
dc.subjectCardiomiopatias/terapia
dc.subjectTransplante de Células/métodos
dc.subjectTransplante de Células/tendências
dc.subjectDoença de Chagas/terapia
dc.subjectAnimais
dc.subjectTransplante de Medula Óssea/métodos
dc.subjectCardiomiopatias/quimioterapia
dc.subjectTransplante de Células/patologia
dc.subjectDoença de Chagas/quimioterapia
dc.subjectDoença Crônica
dc.subjectModelos Animais de Doenças
dc.subjectHumanos
dc.titleCellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy.
dc.typeArticle


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