| dc.creator | Santos, Rafael Ribeiro | |
| dc.creator | Campos, Carli Salviana Maria de | |
| dc.creator | Ferretjans, Rodrigo | |
| dc.creator | Carvalho, Andrea Teixeira de | |
| dc.creator | Martins Filho, Olindo Assis | |
| dc.creator | Teixeira, Antonio Lucio | |
| dc.creator | Salgado, João Vinicius | |
| dc.date | 2020-02-03T13:48:42Z | |
| dc.date | 2020-02-03T13:48:42Z | |
| dc.date | 2019 | |
| dc.date.accessioned | 2023-09-26T20:07:16Z | |
| dc.date.available | 2023-09-26T20:07:16Z | |
| dc.identifier | SANTOS, Rafael Ribeiro et al. The association of cognitive performance and IL-6 levels in schizophrenia is influenced by age and antipsychotic treatment. Nordic Journal of Psychiatry, v. 18, p. 1-7, 2019. | |
| dc.identifier | 0803-9488 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/39673 | |
| dc.identifier | 10.1080/08039488.2019.1688389 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8848963 | |
| dc.description | Aims: Recent findings suggest that cognitive impairment can be associated with inflammation and immune changes in schizophrenia. We aimed to study possible associations between cytokine levels and cognitive performance in a sample of patients with schizophrenia.Methods: Cognition was assessed with the brief assessment of cognition in schizophrenia in 63 clinically stable outpatients with schizophrenia. Blood was collected and cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, TNF-α, IFN-γ) were measured by cytometric bead array method. Psychopathological scales were also applied.Results: IL-6 correlated negatively with general cognitive performance (rho = -0.395, p = .017) and positively with antipsychotic dose (rho = 0.412, p = .004). Multiple regression analysis showed that cognitive performance is associated with age and antipsychotic dose (p = .000 and p = .033).Conclusion: The association between IL-6 levels and cognitive performance is dependent on age and antipsychotic dose. | |
| dc.description | 2040-01-01 | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Informa Healthcare | |
| dc.rights | restricted access | |
| dc.subject | IL-6 | |
| dc.subject | Schizophrenia | |
| dc.subject | Cognition | |
| dc.subject | Inflammation | |
| dc.title | The association of cognitive performance and IL-6 levels in schizophrenia is influenced by age and antipsychotic treatment | |
| dc.type | Article | |
