Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations

dc.creatorKehdy, Fernanda de Souza Gomes
dc.creatorGouveia, Mateus Henrique
dc.creatorMachado, Moara
dc.creatorMagalhães, Wagner Carlos Santos
dc.creatorHorimoto, Andrea Roseli Vançan Russo
dc.creatorHorta, Bernardo Lessa
dc.creatorMoreira, Rennan Garcias
dc.creatorLeal, Thiago P.
dc.creatorScliar, Marilia de Oliveira
dc.creatorSouza, Giordano Bruno Soares
dc.creatorSoares, Fernanda Rodrigues
dc.creatorAraújo, Gilderlanio Santana de
dc.creatorZamudio, Roxana
dc.creatorSant Anna, Hanaisa de Pla e
dc.creatorSantos, Hadassa Cristhina de Azevedo Soares dos
dc.creatorDuarte, Nubia Esteban
dc.creatorFiaccone, Rosemeire Leovigildo
dc.creatorFigueiredo, Camila A.
dc.creatorSilva, Thiago Magalhães de
dc.creatorCosta, Gustavo Nunes de Oliveira
dc.creatorBeleza, Sandra
dc.creatorBerg, Douglas E.
dc.creatorCabrera, Lilia
dc.creatorDuarte, Denise
dc.creatorGhirotto, Silvia
dc.creatorGilman, Robert H
dc.creatorGonçalves, Vanessa F.
dc.creatorMarrero, Andrea Rita
dc.creatorMuniz, Yara C.
dc.creatorWeissensteiner, Hansi
dc.creatorYeager, Meredith
dc.creatorRodrigues, Laura C.
dc.creatorBarreto, Mauricio Lima
dc.creatorCosta, Maria Fernanda Lima
dc.creatorPereira, Alexandre da Costa
dc.creatorRodrigues, Maíra Ribeiro
dc.creatorSantos, Eduardo Martín Tarazona
dc.creatorNeves, Neuza Alcantara
dc.creatorAraújo, Nathalia M.
dc.creatorCarvalho, Márcio L.B.
dc.creatorConceição, Jackson Santos
dc.creatorFirmo, Josélia Oliveira Araújo
dc.creatorGigante, Denise Petrucci
dc.creatorMeira, Lindolfo
dc.creatorQueiroz, Thais Muniz
dc.creatorOliveira, Guilherme Correa de
dc.creatorOliveira, Isabel O.
dc.creatorPeixoto, Sérgio William Viana
dc.creatorProietti, Fernando Augusto
dc.creatorRodrigues, Domingos C.
dc.creatorSantolalla, Meddly L.
dc.creatorStrina, Agostino
dc.creatorZolini, Camila
dc.date2016-02-19T13:37:09Z
dc.date2016-02-19T13:37:09Z
dc.date2015
dc.date.accessioned2023-09-26T20:07:09Z
dc.date.available2023-09-26T20:07:09Z
dc.identifierKEHDY, Fernanda de Souza Gomes et al. Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations. Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28): 8696–8701.
dc.identifier0027-8424
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/12757
dc.identifier10.1073/pnas.1504447112
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8848904
dc.descriptionWhile South Americans are underrepresented in human genomic diversity studies, Brazil has been a classical model for population genetics studies on admixture.We present the results of the EPIGEN Brazil Initiative, the most comprehensive up-to-date genomic analysis of any Latin-American population. A population-based genomewide analysis of 6,487 individuals was performed in the context of worldwide genomic diversity to elucidate how ancestry, kinship, and inbreeding interact in three populations with different histories from the Northeast (African ancestry: 50%), Southeast, and South (both with European ancestry >70%) of Brazil. We showed that ancestry-positive assortative mating permeated Brazilian history. We traced European ancestry in the Southeast/South to a wider European/Middle Eastern region with respect to the Northeast, where ancestry seems restricted to Iberia. By developing an approximate Bayesian computation framework, we infer more recent European immigration to the Southeast/South than to the Northeast. Also, the observed low Native-American ancestry (6–8%) was mostly introduced in different regions of Brazil soon after the European Conquest. We broadened our understanding of the African diaspora, the major destination of which was Brazil, by revealing that Brazilians display two within-Africa ancestry components: one associated with non-Bantu/western Africans (more evident in the Northeast and African Americans) and one associated with Bantu/eastern Africans (more present in the Southeast/South). Furthermore, the whole-genome analysis of 30 individuals (42-fold deep coverage) shows that continental admixture rather than local post-Columbian history is the main and complex determinant of the individual amount of deleterious genotypes.
dc.formatapplication/pdf
dc.languageeng
dc.publisherNational Academy of Sciences
dc.rightsopen access
dc.subjectLatin America
dc.subjectpopulation genetics
dc.subjectSalvador SCAALA
dc.subjectBambuí Cohort Study of Ageing
dc.subjectPelotas Birth Cohort Study
dc.titleOrigin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations
dc.typeArticle


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