Arginase 1 is a marker of protection against illness in contacts of leprosy patients

dc.creatorPrata, Rhana Berto da Silva
dc.creatorMendes, Mayara Abud
dc.creatorSoares, Vinicius Cardoso
dc.creatorCosta, Jaqueline França
dc.creatorSales, Ana Maria
dc.creatorDuppre, Nádia Cristina
dc.creatorBorges, Valéria de Matos
dc.creatorSilva, Tatiana Pereira da
dc.creatorBozza, Patricia Torres
dc.creatorBozza, Marcelo Torres
dc.creatorSarno, Euzenir Nunes
dc.creatorMoraes, Milton Ozório
dc.creatorSilva, Gilberto Marcelo Sperandio da
dc.creatorPinheiro, Roberta Olmo
dc.date2022-06-20T12:26:14Z
dc.date2022-06-20T12:26:14Z
dc.date2022
dc.date.accessioned2023-09-26T20:07:00Z
dc.date.available2023-09-26T20:07:00Z
dc.identifierPRATA, Rhana Berto da Silva et al. Arginase 1 is a marker of protection against illness in contacts of leprosy patients. Scientific Reports, v. 22, 7850, p. 1 - 9, 2022.
dc.identifier2045-2322
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/53364
dc.identifier10.1038/s41598-022-11944-9
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8848841
dc.descriptionLeprosy household contacts are generally more prone to develop the disease compared to the general population. Previous studies have demonstrated that genes related to the alternative activation (M2) profile in macrophages are associated with the increased bacillary load in multibacillary leprosy patients (MB), and that contacts of MB patients have a higher risk of contracting the disease. In addition, positive serological responses to PGL-1 or LID-1 are associated with a higher risk of disease. We performed a 5-year follow-up of contacts of leprosy patients and evaluated the pattern of gene and protein expression in cells from contacts that developed leprosy during this period. Leprosy household contacts had decreased soluble CD163 and heme oxygenase 1 (HO-1) serum levels when compared with healthy donors and leprosy patients. In contrast, arginase 1 activities were higher in contacts when compared with both healthy donors and leprosy patients. Of the contacts, 33 developed leprosy during the follow-up. Gene expression analysis revealed reduced ARG1 expression in these contacts when compared with contacts that did not develop disease. Arginase activity was a good predictive marker of protection in contacts (sensitivity: 90.0%, specificity: 96.77%) and the association with serology for anti-PGL-1 and anti-LID-1 increased the sensitivity to 100%. Altogether, the data presented here demonstrate a positive role of arginase against leprosy and suggest that the evaluation of arginase activity should be incorporated into leprosy control programs in order to aid in the decision of which contacts should receive chemoprophylaxis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherNature Portfolio
dc.rightsopen access
dc.subjectArginase 1
dc.subjectMarcador
dc.subjectProteção contra doenças
dc.subjectPacientes leprosos
dc.subjectArginase 1
dc.subjectMarker of protection
dc.subjectAgainst Illness
dc.subjectLeprosy patients
dc.titleArginase 1 is a marker of protection against illness in contacts of leprosy patients
dc.typeArticle


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