Capsular polysaccharides galactoxylomannan and glucuronoxylomannan from Cryptococcus neoformans induce macrophage apoptosis mediated by Fas ligand

dc.creatorVillena, Suellen N.
dc.creatorPinheiro, Roberta O.
dc.creatorPinheiro, Carla S.
dc.creatorNunes, Marise P.
dc.creatorTakiya, Cristina M.
dc.creatorReis, George A. dos
dc.creatorPreviato, José O.
dc.creatorMendonça-Previato, Lucia
dc.creatorLima, Célio G. Freire de
dc.date2018-09-22T17:06:36Z
dc.date2018-09-22T17:06:36Z
dc.date2008
dc.date.accessioned2023-09-26T20:06:48Z
dc.date.available2023-09-26T20:06:48Z
dc.identifierVILENA, Suellen N. et al. Capsular polysaccharides galactoxylomannan and glucuronoxylomannan from Cryptococcus neoformans induce macrophage apoptosis mediated by Fas ligand. Cellular Microbiology, v.10, n.6, p.1274-1285, 2008.
dc.identifier1462-5814
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/28988
dc.identifier10.1111/j.1462-5822.2008.01125.x
dc.identifier1462-5822
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8848761
dc.descriptionThe effects of capsular polysaccharides, galactoxylomannan (GalXM) and glucuronoxylomannan (GXM), from acapsular (GXM negative) and encapsulate strains of Cryptococcus neoformans were investigated in RAW 264.7 and peritoneal macrophages. Here, we demonstrate that GalXM and GXM induced different cytokines profiles in RAW 264.7 macrophages. GalXM induced production of TNF-alpha, NO and iNOS expression, while GXM predominantly induced TGF-beta secretion. Both GalXM and GXM induced early morphological changes identified as autophagy and late macrophages apoptosis mediated by Fas/FasL interaction, a previously unidentified mechanism of virulence. GalXM was more potent than GXM at induction of Fas/FasL expression and apoptosis on macrophages in vitro and in vivo. These findings uncover a mechanism by which capsular polysaccharides from C. neoformans might compromise host immune responses.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectPolissacarídeos capsulares
dc.subjectapoptose macrofágica
dc.subjectCryptococcus neoformans
dc.subjectProteína Ligante Fas
dc.subjectCapsular polysaccharides
dc.subjectCryptococcus neoformans
dc.subjectmacrophage apoptosis
dc.subjectFas ligand
dc.titleCapsular polysaccharides galactoxylomannan and glucuronoxylomannan from Cryptococcus neoformans induce macrophage apoptosis mediated by Fas ligand
dc.typeArticle


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