Signal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndrome

dc.creatorAlmeida, Vinicius Cotta de
dc.creatorDupré, Löic
dc.creatorGuipouy, Delphine
dc.creatorVasconcelos, Zilton Farias Meira de
dc.date2015-08-19T13:49:20Z
dc.date2015-08-19T13:49:20Z
dc.date2015
dc.date.accessioned2023-09-26T20:06:25Z
dc.date.available2023-09-26T20:06:25Z
dc.identifierALMEIDA, Vinicius Cotta de et al. Signal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndrome. Frontiers in Immunology, v. 6, Article 47, p. 1-11, Feb. 2015.
dc.identifier1664-3224
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/11488
dc.identifier10.3389/fimmu.2015.00047
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8848615
dc.descriptionOver the last decades, research dedicated to the molecular and cellular mechanisms underlying primary immunodeficiencies (PID) has helped to understand the etiology of many of these diseases and to develop novel therapeutic approaches. Beyond these aspects, PID are also studied because they offer invaluable natural genetic tools to dissect the human immune system. In this review, we highlight the research that has focused over the last 20 years on T lymphocytes fromWiskott–Aldrich syndrome (WAS) patients.WAS T lymphocytes are defective for the WAS protein (WASP), a regulator of actin cytoskeleton remodeling. Therefore, study of WAS T lymphocytes has helped to grasp that many steps of T lymphocyte activation and function depend on the crosstalk between membrane receptors and the actin cytoskeleton. These steps include motility, immunological synapse assembly, and signaling, as well as the implementation of helper, regulatory, or cytotoxic effector functions. The recent concept that WASP also works as a regulator of transcription within the nucleus is an illustration of the complexity of signal integration in T lymphocytes. Finally, this review will discuss howfurther study ofWAS may contribute to solve novel challenges of T lymphocyte biology.
dc.formatapplication/pdf
dc.languageeng
dc.publisherUniversity of Washington
dc.rightsopen access
dc.subjectTranscrição
dc.subjectComunicação
dc.subjectWiskott–Aldrich syndrome
dc.subjectT lymphocytes
dc.subjectActin cytoskeleton
dc.subjectMotility
dc.subjectImmunological synapse
dc.subjectSignaling
dc.subjectTranscription
dc.subjectCitoesqueleto de Actina
dc.subjectMotilidade
dc.subjectLinfócitos T
dc.subjectCitoesqueleto de Actina
dc.titleSignal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndrome
dc.typeArticle


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