Systemic immune mediators reflect tumor-infiltrating lymphocyte intensity and predict therapeutic response in triple-negative breast câncer

dc.creatorLopes, Ananda D
dc.creatorGaldino, Nayane A L
dc.creatorFigueiredo, Amanda B
dc.creatorBrianese, Rafael C
dc.creatorMorais, Katia L P
dc.creatorBrot, Marina De
dc.creatorOsório, Cynthia A B T
dc.creatorCarvalho, Andrea Teixeira de
dc.creatorCalsavara, Vinicius F
dc.creatorEvangelista, Guilherme F B
dc.creatorAlves, Natalia S
dc.creatorMakdissi, Fabiana B
dc.creatorSanches, Solange M
dc.creatorLima, Vladmir C Cordeiro de
dc.creatorCarraro, Dirce M
dc.creatorGollob, Kenneth J
dc.date2023-05-11T17:13:08Z
dc.date2023-05-11T17:13:08Z
dc.date2023
dc.date.accessioned2023-09-26T20:06:25Z
dc.date.available2023-09-26T20:06:25Z
dc.identifierLOPES, Ananda D et al. Systemic immune mediators reflect tumor-infiltrating lymphocyte intensity and predict therapeutic response in triple-negative breast cancer. Immunology, 2023. doi: 10.1111/imm.13627.
dc.identifier0019-2805
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/58328
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8848614
dc.descriptionTriple-negative breast cancer (TNBC) is an aggressive form of breast cancer. Neoadjuvant chemotherapy has proven efficacy in its treatment, and a pathological complete response (pCR) to therapy is predictive of improved long-term survival. The immune response is key to successful neoadjuvant chemotherapy, as indicated by the relation between the percentage of stromal tumor-infiltrating lymphocytes (TILs) in pre-treated tumor tissue samples and the likelihood of achieving pCR. Here we studied systemic immune mediators from volunteer TNBC patients before undergoing neoadjuvant chemotherapy to determine the systemic response association with TIL intensity, treatment response and survival. Patients were classified into pCR responder or non-responder at time of surgery. We found higher levels of immune mediators before treatment began in patients that went on to be pCR responders vs. non-pCR, with AUC values of 0.64 - 0.80. We also observed a positive correlation between inflammatory systemic immune mediators and the percentage of TILs in pCR responder patients. Combining TILs and systemic immune mediator levels provided stronger AUC values (range of 0.72 - 0.82). Lastly, performing a progression free survival analysis with several of the systemic cytokines that predict pCR, segregated the patients into long and short survival groups based on high and low production of the cytokines, respectively. Our study demonstrates that circulating cytokines, before treatment begins, predict pCR in TNBC patients treated with neoadjuvant chemotherapy. Moreover, they may act as a surrogate marker of high TILs or together with TILs to better predict pCR and survival.
dc.description2099-12-31
dc.formatapplication/pdf
dc.languageeng
dc.publisherBlackwell Scientific Publications
dc.rightsrestricted access
dc.subjectTILs
dc.subjectTriple negative breast cancer
dc.subjectcytokines
dc.subjectneoadjuvant therapy
dc.subjecttumor immunology
dc.titleSystemic immune mediators reflect tumor-infiltrating lymphocyte intensity and predict therapeutic response in triple-negative breast câncer
dc.typeArticle


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