Chagasic Patients with Indeterminate Clinical Form of the Disease have High Frequencies of Circulating CD3 Þ CD16 –CD56 þNatural Killer T Cells and CD4 þ CD25 High Regulatory T Lymphocytes

dc.creatorAvelar, Danielle Marquete Vitelli
dc.creatorAvelar, Renato Sathler
dc.creatorDias, João Carlos Pinto
dc.creatorPascoal, Vanessa Peruhype Magalhães
dc.creatorCarvalho, Andréa Teixeira de
dc.creatorLage, Paula Souza
dc.creatorSantos, Silvana Maria Elói
dc.creatorOliveira, Rodrigo Corrêa de
dc.creatorMartins Filho, Olindo Assis
dc.date2013-08-21T17:19:52Z
dc.date2013-08-21T17:19:52Z
dc.date2005
dc.date.accessioned2023-09-26T20:06:22Z
dc.date.available2023-09-26T20:06:22Z
dc.identifierAVELAR, Danielle Marquete Vitelli et al. Chagasic Patients with Indeterminate Clinical Form of the Disease have High Frequencies of Circulating CD3 Þ CD16 –CD56 þNatural Killer T Cells and CD4 þ CD25 High Regulatory T Lymphocytes. Scandinavian Journal of Immunology, n. 62, p. 297-308, 2005.
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/6813
dc.identifierdoi: 10.1111/j.1365-3083.2005.01668.x
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8848602
dc.descriptionSeveral studies have demonstrated that different clinical manifestations of human Chagas’ disease are associated with distinct and complex host–parasite relationships directly involving the immune system. In this context, it has been proposed that tissue damage might be more severe in the absence of regulatory mechanisms that involve both innate and adaptive immune responses. Herein, we describe a descriptive phenotypic profile focusing on the frequency of major regulatory T cells [CD4 þ CD25 high and natural killer T (NKT) lymphocytes] in different clinical forms of Chagas’ disease. Ex vivo immunophenotyping of whole blood demonstrated that the indeterminate clinical form displays a higher frequency of both CD4 þ CD25 high and NKT regulatory cells (CD3 þ CD16 – CD56 þ ), associated with increased levels of circulating cytotoxic NK cells (CD3 – CD16 þ CD56 þ and CD3 – CD16 þ CD56 dim NK cells). By con-trast, the increased percentage of activated CD8 þ HLA-DR þ T-cell subset was exclusively associated with severe clinical forms of Chagas’ disease. We hypothe-size that regulatory T cells may be able to control the deleterious cytotoxic activity in the indeterminate clinical form by inhibiting the activation of CD8 þ HLA-DR þ T cells. The lack of regulated populations in cardiac and digestive clinical forms could account for impaired immune response that culminates in strong cytotoxic activity and tissue damage.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBlackwell Publishing
dc.rightsrestricted access
dc.subjectChagas’ disease
dc.subjectTrypanosoma cruzi
dc.titleChagasic Patients with Indeterminate Clinical Form of the Disease have High Frequencies of Circulating CD3 Þ CD16 –CD56 þNatural Killer T Cells and CD4 þ CD25 High Regulatory T Lymphocytes
dc.typeArticle


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