dc.contributor | Universidade Estadual Paulista (UNESP) | |
dc.creator | Messora, M. R. | |
dc.creator | Nagata, Maria José Hitomi | |
dc.creator | Mariano, R. C. | |
dc.creator | Dornelles, Rita Cassia Menegati | |
dc.creator | Bomfim, Suely Regina Mogami | |
dc.creator | Fucini, S. E. | |
dc.creator | Garcia, Valdir Gouveia | |
dc.creator | Bosco, Álvaro Francisco | |
dc.date | 2014-05-20T15:32:50Z | |
dc.date | 2016-10-25T18:09:11Z | |
dc.date | 2014-05-20T15:32:50Z | |
dc.date | 2016-10-25T18:09:11Z | |
dc.date | 2008-04-01 | |
dc.date.accessioned | 2017-04-06T00:29:47Z | |
dc.date.available | 2017-04-06T00:29:47Z | |
dc.identifier | Journal of Periodontal Research. Oxford: Blackwell Publishing, v. 43, n. 2, p. 217-223, 2008. | |
dc.identifier | 0022-3484 | |
dc.identifier | http://hdl.handle.net/11449/41627 | |
dc.identifier | http://acervodigital.unesp.br/handle/11449/41627 | |
dc.identifier | 10.1111/j.1600-0765.2007.01017.x | |
dc.identifier | WOS:000253480700013 | |
dc.identifier | http://dx.doi.org/10.1111/j.1600-0765.2007.01017.x | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/884314 | |
dc.description | Background and objective: The purpose of this study was to analyze histologically the influence of autologous platelet-rich plasma on bone healing in surgically created critical-size defects in rat calvaria.Material adn Methods: Thirty-two rats were divided into two groups: the control group (group C) and the platelet-rich plasma group. An 8-mm-diameter critical-size defect was created in the calvarium of each animal. In group C the defect was filled by a blood clot only. In the platelet-rich plasma group, 0.35 mL of platelet-rich plasma was placed in the defect and covered by 0.35 mL of platelet-poor plasma. Both groups were divided into subgroups (n = 8) and killed at either 4 or 12 wk postoperatively. Histometric (using image-analysis software) and histologic analyses were performed. The amount of new bone formed was calculated as a percentage of the total area of the original defect. Percentage data were transformed into arccosine for statistical analysis (analysis of variance, Tukey, p < 0.05).Results: No defect completely regenerated with bone. The platelet-rich plasma group had a statistically greater amount of bone formation than group C at both 4 wk (17.68% vs. 7.20%, respectively) and 12 wk (24.69% vs. 11.65%, respectively) postoperatively.Conclusion: Within the limits of this study, it can be concluded that platelet-rich plasma placed in the defects and covered by platelet-poor plasma significantly enhanced bone healing in critical-size defects in rat calvaria. | |
dc.language | eng | |
dc.publisher | Blackwell Publishing | |
dc.relation | Journal of Periodontal Research | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | bone regeneration | |
dc.subject | growth factors | |
dc.subject | in vivo model | |
dc.subject | platelets | |
dc.title | Bone healing in critical-size defects treated with platelet-rich plasma: a histologic and histometric study in rat calvaria | |
dc.type | Otro | |