Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus Venom

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSangiorgio, F.
dc.creatorSakate, M.
dc.creatorNogueira, R. M. B.
dc.creatorTostes, R. A.
dc.date2014-05-20T15:32:36Z
dc.date2016-10-25T18:08:54Z
dc.date2014-05-20T15:32:36Z
dc.date2016-10-25T18:08:54Z
dc.date2008-01-01
dc.date.accessioned2017-04-06T00:28:40Z
dc.date.available2017-04-06T00:28:40Z
dc.identifierJournal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 14, n. 1, p. 82-99, 2008.
dc.identifier1678-9199
dc.identifierhttp://hdl.handle.net/11449/41469
dc.identifierhttp://acervodigital.unesp.br/handle/11449/41469
dc.identifierS1678-91992008000100007
dc.identifierWOS:000254511600007
dc.identifierS1678-91992008000100007.pdf
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992008000100007
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/884172
dc.descriptionThe present work evaluated histopathological aspects in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into three groups of seven animals each: Group I only venom; Group II - venom + 50ml antiophidic serum + fluid therapy; Group III venom + 50ml antiophidic serum + fluid therapy + urine alkalization. Lyophilized venom of Crotalus durissus terrificus was reconstituted in saline solution and inoculated subcutaneously at the dose of 1mg/kg body weight. Three animals of each group were subjected to euthanasia, and their muscular tissue, brain, spleen, kidneys, heart, lungs, stomach, small and large intestines, and popliteal lymph node fragments were collected for histopathological evaluation. There was myonecrosis in the inoculated limb, renal tubular degeneration, lymphoid hyperplasia of spleen, and unspecific reactive hepatitis. These results show the antigenicity and action of the venom on the immune system.
dc.languageeng
dc.publisherUniversidade Estadual Paulista (UNESP), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)
dc.relationJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthistopathology
dc.subjectCrotalus durissus terrificus
dc.subjectdogs
dc.subjecttreatment
dc.subjectintoxication
dc.titleHistopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus Venom
dc.typeOtro


Este ítem pertenece a la siguiente institución