Treatment of Pythiosis in Equine Limbs Using Intravenous Regional Perfusion of Amphotericin B

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorDoria, Renata G. S.
dc.creatorFreitas, Silvio H.
dc.creatorLinardi, Renata L.
dc.creatorMendonca, Fabio de Souza
dc.creatorArruda, Laura P.
dc.creatorBoabaid, Fabiana M.
dc.creatorValadao, Carlos A. A.
dc.date2014-05-20T15:32:11Z
dc.date2016-10-25T18:08:20Z
dc.date2014-05-20T15:32:11Z
dc.date2016-10-25T18:08:20Z
dc.date2012-08-01
dc.date.accessioned2017-04-06T00:26:21Z
dc.date.available2017-04-06T00:26:21Z
dc.identifierVeterinary Surgery. Hoboken: Wiley-blackwell, v. 41, n. 6, p. 759-765, 2012.
dc.identifier0161-3499
dc.identifierhttp://hdl.handle.net/11449/41156
dc.identifierhttp://acervodigital.unesp.br/handle/11449/41156
dc.identifier10.1111/j.1532-950X.2012.01019.x
dc.identifierWOS:000307225300015
dc.identifierhttp://dx.doi.org/10.1111/j.1532-950X.2012.01019.x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/883875
dc.descriptionObjective To evaluate the effects of intravenous regional limb perfusion (IRLP) administration of amphotericin B in horses to treat pythiosis after surgical excision and thermocautery. Study Design Case series. Animals Horses (n = 12) with Pythium insidiosum infection of the distal aspect of the thoracic or pelvic limbs. Methods After surgical excision of granulation tissue and thermocautery, 50 mg amphotericin B was administered by IRLP through a catheter placed in a superficial vein of the affected limb next to the lesion after placing a tourniquet above the injection site. The lesions and locomotor system were evaluated before treatment and at 7, 14, 21, 28, 35, and 60 days. Results Ninety-two percent of horses treated with amphotericin B had complete lesion resolution 35 or 60 days after 1 or 2 IRLP treatments, respectively. IRLP induced limb edema and pain during regional palpation in 42%, and inflammation of the injection site in 33% of horses; however these signs resolved after 14 days. Conclusions IRLP administration of amphotericin B was effective for treating pythiosis in equine limbs, resolving infection with manageable side effects.
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationVeterinary Surgery
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleTreatment of Pythiosis in Equine Limbs Using Intravenous Regional Perfusion of Amphotericin B
dc.typeOtro


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