Immunohistochemical evaluation of prostaglandin E2 and vascular endothelial growth factor in canine cutaneous mast cell tumours

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorAmorim, Renée Laufer
dc.creatorPinczowski, P.
dc.creatorNeto, R. T.
dc.creatorRahal, Sheila Canevese
dc.date2014-05-20T15:32:07Z
dc.date2016-10-25T18:08:15Z
dc.date2014-05-20T15:32:07Z
dc.date2016-10-25T18:08:15Z
dc.date2010-03-01
dc.date.accessioned2017-04-06T00:26:02Z
dc.date.available2017-04-06T00:26:02Z
dc.identifierVeterinary and Comparative Oncology. Malden: Wiley-blackwell Publishing, Inc, v. 8, n. 1, p. 23-27, 2010.
dc.identifier1476-5810
dc.identifierhttp://hdl.handle.net/11449/41111
dc.identifierhttp://acervodigital.unesp.br/handle/11449/41111
dc.identifier10.1111/j.1476-5829.2009.00202.x
dc.identifierWOS:000273912000003
dc.identifier0000-0002-9211-4093
dc.identifierhttp://dx.doi.org/10.1111/j.1476-5829.2009.00202.x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/883832
dc.descriptionVascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE-2) appear to play a critical role in tumour neovascularization. In this study, we have investigated the expression of VEGF and PGE-2 in 53 canine cutaneous mast cell tumours (MCTs). Immunohistochemistry of tissue sections revealed that VEGF and PGE-2 were expressed in all mast cell tumours studied. When the expression patterns of VEGF and PGE-2 were compared with tumour grade according to Patnaik criteria, the only significant correlation observed was between PGE-2 staining intensity and tumour pathological grade, with grade II and III tumours having higher PGE-2 staining, both in intensity and percentage of cells stained, than grade I tumours (P < 0.05).
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherWiley-Blackwell Publishing, Inc
dc.relationVeterinary and Comparative Oncology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectangiogenesis
dc.subjectcanine
dc.subjectmast cell tumour
dc.subjectPGE-2
dc.subjectVEGF
dc.titleImmunohistochemical evaluation of prostaglandin E2 and vascular endothelial growth factor in canine cutaneous mast cell tumours
dc.typeOtro


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