LC-DAD Determination of Fleroxacin in Bulk and Pharmaceutical Dosage Forms

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSalgado, Hérida Regina Nunes
dc.creatorMoreno, Andreia
dc.creatorGarg, Sanjay
dc.date2014-05-20T15:32:03Z
dc.date2016-10-25T18:08:09Z
dc.date2014-05-20T15:32:03Z
dc.date2016-10-25T18:08:09Z
dc.date2009-06-01
dc.date.accessioned2017-04-06T00:25:37Z
dc.date.available2017-04-06T00:25:37Z
dc.identifierChromatographia. Wiesbaden: Vieweg, v. 69, p. 237-240, 2009.
dc.identifier0009-5893
dc.identifierhttp://hdl.handle.net/11449/41051
dc.identifierhttp://acervodigital.unesp.br/handle/11449/41051
dc.identifier10.1365/s10337-009-1053-8
dc.identifierWOS:000267330400021
dc.identifierhttp://dx.doi.org/10.1365/s10337-009-1053-8
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/883778
dc.descriptionFleroxacin is a third generation fluoroquinolone with broad spectrum antibacterial activity. In this work an LC-DAD method for the analysis of fleroxacin was developed and validated using UV detection at 286 nm. The method was validated for linearity, precision, robustness, LOD, LOQ, specificity and accuracy at concentrations of 0.2-20.0 mu g mL(-1) and r (2) = 1. The LOD and LOQ were 0.059 and 0.197 mu g, respectively, the recoveries were 99.92-102.0% and the CV was less than 2.0%. The LC-DAD validated method provided analytical sensitivity, specificity and reproducibility suitable for quality control analysis.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherVieweg
dc.relationChromatographia
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectColumn liquid chromatography
dc.subjectLiquid chromatography-diode array detection
dc.subjectQuality control
dc.subjectFleroxacin
dc.titleLC-DAD Determination of Fleroxacin in Bulk and Pharmaceutical Dosage Forms
dc.typeOtro


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