K-ATP(+) Channels-Independent Analgesic Action of Crotalus durissus cumanensis venom

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorPereira, Ticiana Praciano
dc.creatorCampos, Adriana Rolim
dc.creatorLeal, Luzia Kalyne A. M.
dc.creatorPierdona, Taiana Magalhaes
dc.creatorToyama, Marcos H.
dc.creatorAzul Monteiro, Helena Serra
dc.creatorCosta Martins, Alice Maria
dc.date2014-05-20T15:31:20Z
dc.date2016-10-25T18:07:08Z
dc.date2014-05-20T15:31:20Z
dc.date2016-10-25T18:07:08Z
dc.date2010-07-01
dc.date.accessioned2017-04-06T00:21:43Z
dc.date.available2017-04-06T00:21:43Z
dc.identifierNatural Product Communications. Westerville: Natural Products Inc, v. 5, n. 7, p. 1103-1106, 2010.
dc.identifier1934-578X
dc.identifierhttp://hdl.handle.net/11449/40506
dc.identifierhttp://acervodigital.unesp.br/handle/11449/40506
dc.identifierWOS:000280117300025
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/883274
dc.descriptionThe effect was investigated of the K+ channel blocker, glibenclamide, on the ability of Crotalus durissus cumanensis venom (CDCM) to promote peripheral antinociception. This was measured by formalin-induced nociception in male Swiss mice. CDCM (200 and 300 mu g/kg) produced an antinociceptive effect during phase 2 in the formalin test. The effect of CDCM (200 mu g/kg) was unaffected by the ATP-sensitive K+ channel blocker glibenclamide (2 mg/kg). These results suggest that CDCM is effective against acute pain. However, the ATP-sensitive K+ channels pathway is not contributable to the antinoeiceptive mechanism of CDCM.
dc.languageeng
dc.publisherNatural Products Inc
dc.relationNatural Product Communications
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCrotalus durissus cumanensis venom
dc.subjectnociception
dc.subjectglibenclamide
dc.titleK-ATP(+) Channels-Independent Analgesic Action of Crotalus durissus cumanensis venom
dc.typeOtro


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