The analgesic effect of crotoxin on neuropathic pain is mediated by central muscarinic receptors and 5-lipoxygenase-derived mediators

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorNogueira-Neto, Francisco de Sousa
dc.creatorAmorim, Renée Laufer
dc.creatorBrigatte, Patricia
dc.creatorPicolo, Gisele
dc.creatorFerreira, Wilson A.
dc.creatorGutierrez, Vanessa R.
dc.creatorConceicao, Isaltino Marcelo
dc.creatorDella-Casa, Maisa S.
dc.creatorTakahira, Regina Kiomi
dc.creatorNicoletti, Jose Luis M.
dc.creatorCury, Yara
dc.date2014-05-20T15:30:54Z
dc.date2016-10-25T18:06:35Z
dc.date2014-05-20T15:30:54Z
dc.date2016-10-25T18:06:35Z
dc.date2008-12-01
dc.date.accessioned2017-04-06T00:19:32Z
dc.date.available2017-04-06T00:19:32Z
dc.identifierPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V. Ltd, v. 91, n. 2, p. 252-260, 2008.
dc.identifier0091-3057
dc.identifierhttp://hdl.handle.net/11449/40189
dc.identifierhttp://acervodigital.unesp.br/handle/11449/40189
dc.identifier10.1016/j.pbb.2008.08.016
dc.identifierWOS:000261549900006
dc.identifier0000-0003-3323-4199
dc.identifierhttp://dx.doi.org/10.1016/j.pbb.2008.08.016
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/882990
dc.descriptionCrotoxin (CTX). a neurotoxin isolated from the venom of the South American rattlesnake Crotalus durissus terrificus. induces analgesia. In this study, we evaluated the antinociceptive effect of CTX in a model of neuropathic pain induced by rat sciatic nerve transection. Hyperalgesia was detected 2 h after nerve transection and persisted for 64 days. Immersion of proximal and distal nerve stumps in CTX solution (0.01 mM for 10 s), immediately after nerve transection, blocked hyperalgesia. The antinociceptive effect of CTX was long-lasting, since it was detected 2 h after treatment and persisted for 64 days. CTX also delayed, but did not block, neurectomy-induced neuroma formation. The effect of CTX was blocked by zileuton (100 mg/kg, p.o.) and atropine (10 mg/kg. i.p.), and reduced by yohimbine (2 mg/kg, i.p.) and methysergide (5 mg/kg, i.p.). on the other hand. indomethacin (4 mg/kg, i.v.). naloxone (1 mg/kg, i.p.). and N-methyl atropine (30 mg/kg, i.p.) did not interfere with the effect of CTX. These results indicate that CTX induces a long-lasting antinociceptive effect in neuropathic pain, which is mediated by activation of central muscarinic receptors and partially, by activation of alpha-adrenoceptors and 5-HT receptors. Eicosanoids derived from the lipoxygenase pathway modulate the action of crotoxin. (C) 2008 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relationPharmacology Biochemistry and Behavior
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCrotoxin
dc.subjectAntinociception
dc.subjectNeuropathic pain
dc.subjectEicosanoids
dc.subjectMuscarinic receptors
dc.subjectCrotalus durissus terrificus venom
dc.titleThe analgesic effect of crotoxin on neuropathic pain is mediated by central muscarinic receptors and 5-lipoxygenase-derived mediators
dc.typeOtro


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