Differential vascular adaptive response in spontaneously hypertensive and Wistar rats: Role of nitric oxide, and prehypertensive and hypertensive states

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCordellini, Sandra
dc.creatorNovo, Rosangela
dc.creatorLanza Junior, Ubirajara
dc.date2014-05-20T15:30:14Z
dc.date2016-10-25T18:05:41Z
dc.date2014-05-20T15:30:14Z
dc.date2016-10-25T18:05:41Z
dc.date2006-07-10
dc.date.accessioned2017-04-06T00:15:58Z
dc.date.available2017-04-06T00:15:58Z
dc.identifierLife Sciences. Oxford: Pergamon-Elsevier B.V., v. 79, n. 7, p. 646-653, 2006.
dc.identifier0024-3205
dc.identifierhttp://hdl.handle.net/11449/39673
dc.identifierhttp://acervodigital.unesp.br/handle/11449/39673
dc.identifier10.1016/j.lfs.2006.02.007
dc.identifierWOS:000238873500006
dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2006.02.007
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/882530
dc.descriptionStress-induced vascular adaptive response in SHR was investigated, focusing on the endothelium. Noradrenaline responses were studied in intact and denuded aortas from 6-week-old (prehypertensive) and 14-week-old (hypertensive) SHR and age-matched Wistar rats submitted or not to acute stress (20-min swimming and I-h immobilization 25 min apart), preceded or not by chronic stress (2 sessions 2 days apart of 1-h day immobilization for 5-consecutive days). Stress did not alter the reactivity of denuded aorta. Moreover, no alteration in the EC50 values was observed after stress exposure. In intact aortas, acute stress-induced hyporeactivity to noradrenaline similar between strains at both age. Chronic stress potentiated this adaptive response in 6- and 14-week-old Wistar but not in 6-week-old SHR, and did not alter the reactivity of 14-week-old SHR. Maximum response (g) in intact aortas [6-week-old: Wistar 3.25 +/- 0.12, Wistar/acute 1.95 +/- 0.12*, Wistar/chronic 1.36 +/- 0.21*(+), SHR 1.75 +/- 0.11, SHR/acute 0.88 +/- 0.08*, SHR/chronic 0.85 +/- 0.05*; 14-week-old: Wistar 3.83 +/- 0.13, Wistar/acute 2.72 +/- 0.13*, Wistar/chronic 1.91 +/- 0.19*', SHR 4.03 +/- 0.17, SHR/acute 2.26 +/- 0.12*, SHR/chronic 4.10 +/- 0.23; inside the same strain: *P < 0.05 relate to non-stressed rat, (+)P < 0.05 related to acute stressed rat; n = 6-18]. Independent of age and strain, L-NAME and endothelium removal abolished the stress-induced aorta hyporeactivity. Conclusion: the vascular adaptive response to stress is impaired in SHR, independently of the hypertensive state. Moreover, this vascular adaptive response is characterized by endothelial nitric oxide-system hyperactivity in both strains. (c) 2006 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationLife Sciences
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectstress
dc.subjecthypertensive state
dc.subjectendothelium
dc.subjectSHR
dc.subjectaorta
dc.subjectvascular reactivity
dc.titleDifferential vascular adaptive response in spontaneously hypertensive and Wistar rats: Role of nitric oxide, and prehypertensive and hypertensive states
dc.typeOtro


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