Quantification of sphingosine-1-phosphate (S1P) in patients with periodontitis stage II grade B

dc.creatorGarcía-Parra,María I.
dc.creatorJiménez-Coello,Matilde
dc.creatorCarrillo-Ávila,Bertha A.
dc.creatorSauri-Esquivel,Eduardo A.
dc.creatorMartínez-Aguilar,Víctor M.
dc.creatorChávez-Cortéz,Elda G.
dc.date2022-04-01
dc.date.accessioned2023-09-25T14:34:36Z
dc.date.available2023-09-25T14:34:36Z
dc.identifierhttp://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S2215-34112022000100147
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8822474
dc.descriptionAbstract The aim of this study was the quantification of Sphingosine-1-phosphate (S1P) in periodontal pockets of patients with periodontitis. This is an observational, descriptive, case-control study. Thirty subjects were selected: 15 controls and 15 cases. A periodontal study was conducted following the parameters of AAP 2017 for the diagnosis of periodontal diseases. A sample of saliva and gingival crevicular fluid was obtained from each subject and then analyzed with the Human S1P Elisa kit (MyBioSource #MBS2516132) accordingly to the manufacturer's instructions, in order to verify the presence of S1P and quantify it´s concentration when founded. Results showed a significant difference (p=0.05) between cases and controls. In the case of saliva samples, the concentration of S1P was higher than the ones found in the control group (72.94 ng/mL and 45.12 ng/mL). For GCF, a higher amount of S1P was found in patients with POD (20.09 ng/mL and 15.20 ng/mL). This work raises a possible route of bone metabolism, inflammatory process, and identification of periodontitis through oral quantification of S1P, however, future studies are needed.
dc.formattext/html
dc.languageen
dc.publisherFacultad de Odontología. Universidad de Costa Rica
dc.relation10.15517/ijds.2022.48877
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceOdovtos International Journal of Dental Sciences v.24 n.1 2022
dc.subjectPeriodontitis
dc.subjectSphingosine-1-Phosphate
dc.subjectOsteoclastogenesis
dc.subjectInflammation
dc.subjectSaliva
dc.subjectGingival crevicular fluid
dc.titleQuantification of sphingosine-1-phosphate (S1P) in patients with periodontitis stage II grade B
dc.typeinfo:eu-repo/semantics/article


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