EFFECTS OF 2,4-DICHLOROPHENOXYACETIC ACID (2,4-D) ON OPEN-FIELD BEHAVIOR AND NEUROCHEMICAL PARAMETERS OF RATS

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorOliveira, G. H.
dc.creatorPalermoneto, J.
dc.date2014-05-20T15:29:44Z
dc.date2016-10-25T18:05:00Z
dc.date2014-05-20T15:29:44Z
dc.date2016-10-25T18:05:00Z
dc.date1993-08-01
dc.date.accessioned2017-04-06T00:13:14Z
dc.date.available2017-04-06T00:13:14Z
dc.identifierPharmacology & Toxicology. Copenhagen: Munksgaard Int Publ Ltd, v. 73, n. 2, p. 79-85, 1993.
dc.identifier0901-9928
dc.identifierhttp://hdl.handle.net/11449/39245
dc.identifierhttp://acervodigital.unesp.br/handle/11449/39245
dc.identifier10.1111/j.1600-0773.1993.tb01540.x
dc.identifierWOS:A1993LX58200004
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0773.1993.tb01540.x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/882175
dc.descriptionThe effects of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) on the central nervous system (CNS) were studied in rats. Behavioural and neurochemical studies were performed. Results show that acute and oral administration of dimethylamine 2,4-D was able to decrease locomotion and rearing frequencies and to increase immobility duration of rats observed in an open-field test. Treatment of rats with p-chlorophenylalanine (PCPA) was unable to change rat's open-field behaviour; 5-hydroxytryptophan (5-HTP) administration not only increased locomotion and rearing frequences but also decreased immobility duration. Pretreatment of the rats with PCPA and 5-HTP decreased and increased dimethylamine 2,4-D effects, respectively. The herbicide was not able to change the striatal levels of dopamine and homovanilic acid but decreased the striatal levels of serotonin (5-HT), as observed for the doses of 100 and 200 mg/kg and increased those of 5-hydroxyindoleacetic acid (5-HIAA) as measured after the 200 mg/kg dose treatment. When the levels of serotonin and 5-HIAA were measured at the brain stem level, only those of 5-HIAA were modified, being increased by diethylamine 2,4-D (60; 100 and 200 mg/kg); this increment on 5-HIAA levels was observed even 1 hr after pesticide administration. Further analysis showed that 2,4-D concentrations chromatographycally detected both in serum and brain of the intoxicated animals were dose-dependent, being found as early as 1 hr after the smaller dose of the herbicide used (10 mg/kg). The results suggest that diethylamine 2,4-D modify 5-HT functional activity within the CNS. Thus, the effects of the herbicide on open-field behaviour of rats could be attributed to a direct or indirect pesticide action on serotoninergic systems.
dc.languageeng
dc.publisherMunksgaard Int Publ Ltd
dc.relationPharmacology & Toxicology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleEFFECTS OF 2,4-DICHLOROPHENOXYACETIC ACID (2,4-D) ON OPEN-FIELD BEHAVIOR AND NEUROCHEMICAL PARAMETERS OF RATS
dc.typeOtro


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