| dc.contributor | Universidade Estadual Paulista (UNESP) | |
| dc.creator | Alexandre-Moreira, M. S. | |
| dc.creator | Viegas, C. | |
| dc.creator | de Miranda, ALP | |
| dc.creator | Bolzani, Vanderlan da Silva | |
| dc.creator | Barreiro, E. J. | |
| dc.date | 2014-05-20T15:29:43Z | |
| dc.date | 2016-10-25T18:04:58Z | |
| dc.date | 2014-05-20T15:29:43Z | |
| dc.date | 2016-10-25T18:04:58Z | |
| dc.date | 2003-09-01 | |
| dc.date.accessioned | 2017-04-06T00:13:08Z | |
| dc.date.available | 2017-04-06T00:13:08Z | |
| dc.identifier | Planta Medica. Stuttgart: Georg Thieme Verlag Kg, v. 69, n. 9, p. 795-799, 2003. | |
| dc.identifier | 0032-0943 | |
| dc.identifier | http://hdl.handle.net/11449/39230 | |
| dc.identifier | http://acervodigital.unesp.br/handle/11449/39230 | |
| dc.identifier | WOS:000186249500002 | |
| dc.identifier | http://www.ncbi.nlm.nih.gov/pubmed/14598202 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/882162 | |
| dc.description | The antinociceptive activity of (-)-spectaline (1), a piperidine alkaloid isolated from Cassia leptophylla Vog. (Leguminosae), was investigated. We have also studied the acute oral toxicity of 1 in mice and it did not show any signals of toxicity in doses lower than 400 mumol/kg. The antinociceptive effect of 1 was evaluated on chemical (acetic acid, formalin and capsaicin) and thermal (hot plate and tail flick) pain models in mice, using classical standard drugs. Dipyrone ID50 = 14.68 mumol/kg (4.8 mg/kg), in-domethacin ID50 = 0.78 mumol/kg (0.28 mg/kg) and (-)-spectaline ID50 = 48.49 mumol/kg (15.75 mg/kg), all produced a significant inhibition of acetic acid-induced abdominal writhing in mice. (-)-Spectaline was inactive in the hyperalgesic model of formalin and did not show any central analgesic activity (hot plate and tail flick models). In the capsaicin-induced neurogenic pain model, (-)-spectaline presented an important inhibitory effect with an ID50 = 20.81 mug/paw and dipyrone ID50 = 19.89 mug/ paw. The ensemble of results permitted us to identify 1 as an antinociceptive compound. The mechanism underlying this antinociceptive effect of 1 remains unknown, but the results suggest that such an effect could be related to pathways associated to vanilloid receptor systems. | |
| dc.language | eng | |
| dc.publisher | Georg Thieme Verlag Kg | |
| dc.relation | Planta Medica | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | Cassia leptophylla vog. | |
| dc.subject | Leguminosae | |
| dc.subject | (-)-spectaline | |
| dc.subject | antinociceptive | |
| dc.title | Antinociceptive profile of (-)-spectaline: A piperidine alkaloid from Cassia leptophylla | |
| dc.type | Otro | |
