Investigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara .1.

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCarvalho, JCT
dc.creatorSilva, MFC
dc.creatorMaciel, MAM
dc.creatorPinto, Abedala Derbli
dc.creatorNunes, D. S.
dc.creatorLima, R. M.
dc.creatorBastos, J. K.
dc.creatorSarti, S. J.
dc.date2014-05-20T15:29:28Z
dc.date2016-10-25T18:04:44Z
dc.date2014-05-20T15:29:28Z
dc.date2016-10-25T18:04:44Z
dc.date1996-10-01
dc.date.accessioned2017-04-06T00:12:10Z
dc.date.available2017-04-06T00:12:10Z
dc.identifierPlanta Medica. Stuttgart: Georg Thieme Verlag, v. 62, n. 5, p. 402-404, 1996.
dc.identifier0032-0943
dc.identifierhttp://hdl.handle.net/11449/39058
dc.identifierhttp://acervodigital.unesp.br/handle/11449/39058
dc.identifier10.1055/s-2006-957925
dc.identifierWOS:A1996VQ03600004
dc.identifierhttp://dx.doi.org/10.1055/s-2006-957925
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/882039
dc.descriptionThe anti-inflammatory and antinociceptive effects of trans-dehydrocrotonin, isolated from the bark of Croton cajucara (Euphorbiaceae), were investigated using several animal models. The trans-dehydrocrotonin produced a significant inhibition of carrageenin-induced paw edema and cotton pellet granuloma in rats. It also inhibited the writhings in mice induced by acetic acid, but did not show a significant effect in the hot-plate test in mice. The LD(50) of t-DCTN was 555.0 mg/kg (p.o.) for mice.
dc.languageeng
dc.publisherGeorg Thieme Verlag
dc.relationPlanta Medica
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCroton cajucara
dc.subjectEuphorbiaceae
dc.subjecttrans-dehydrocrotonin
dc.subject19-nor-clerodane diterpene
dc.subjectanti-inflammatory and antinociceptive
dc.titleInvestigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara .1.
dc.typeOtro


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