INFLUENCE OF DIABETES-MELLITUS ON THE GLUTATHIONE REDOX SYSTEM OF HUMAN RED-BLOOD-CELLS

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMatsubara, Luiz Shiguero
dc.creatorFerreira, ALA
dc.creatorTornero, MTT
dc.creatorMachado, PEA
dc.date2014-05-20T15:29:15Z
dc.date2016-10-25T18:04:29Z
dc.date2014-05-20T15:29:15Z
dc.date2016-10-25T18:04:29Z
dc.date1992-01-01
dc.date.accessioned2017-04-06T00:11:08Z
dc.date.available2017-04-06T00:11:08Z
dc.identifierBrazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 25, n. 4, p. 331-335, 1992.
dc.identifier0100-879X
dc.identifierhttp://hdl.handle.net/11449/38875
dc.identifierhttp://acervodigital.unesp.br/handle/11449/38875
dc.identifierWOS:A1992HT30200002
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/881904
dc.descriptionSeveral components of the erythrocyte-dependent glutathione redox system (reduced glutathione, GSH; oxidized glutathione, GSSG; glutathione peroxidase, GSH-Px; glutathione reductase, GSH-Red) were determined in patients with types I and II diabetes mellitus (DM). All groups studied were male subjects: G1, 20 young healthy individuals (aged 23.7 +/- 4.2 years); G2, 15 young insulin-treated type I DM patients; G3, 20 older insulin-treated type II DM patients; 04, 21 older oral hypoglycemic agent-treated type II DM patients; G5, 28 aged healthy individuals (aged 68.9 +/- 11.5 years). There were no differences between G1 and G2, G3 or G4 regarding erythrocyte GSH, GSSG, and GSH-Red (without FAD) levels. GSH-Px activity was significantly lower in G2 when compared to G1 (15.2 +/- 4.9 vs 20.6 +/- 6.6 IU/g Hb). The GSH-Red and GSH-Px activities and GSH levels were significantly higher in 03 (4.6 +/- 1.7 IU/g Hb, 20.2 +/- 8.7 IU/g Hb and 3.5 +/- 1.3-mu-M/g Hb) and G4 (5.0 +/- 2.2 IU/g Hb, 16.9 +/- 6.1 IU/g Hb and 5.0 +/- 2.3-mu-M/g Hb) when compared to G5 (3.4 +/- 0.9 IU/g Hb, 12.0 +/- 3.6 IU/g Hb and 2.3 +/- 0.9-mu-M/g Hb). The findings suggest that treatment of DM can stimulate the redox activity of red blood cells in aged subjects.
dc.languageeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGLUTATHIONE
dc.subjectGLUTATHIONE PEROXIDASE
dc.subjectGLUTATHIONE REDUCTASE
dc.subjectDIABETES-MELLITUS
dc.subjectGLYCOSYLATED HEMOGLOBIN
dc.titleINFLUENCE OF DIABETES-MELLITUS ON THE GLUTATHIONE REDOX SYSTEM OF HUMAN RED-BLOOD-CELLS
dc.typeOtro


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