Investigations on the new free radical scavenger polynitroxyl-albumin to prevent ischemia and reperfusion injury after orthotopic heart transplantation in the pig model

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMartin, Juergen
dc.creatorLutter, Georg
dc.creatorSarai, Koppany
dc.creatorSenn-Grossberger, Mareike
dc.creatorTakahashi, Noriyuki
dc.creatorBitu-Moreno, José
dc.creatorHaberstroh, Joerg
dc.creatorBeyersdorf, Friedhelm
dc.date2014-05-20T15:28:40Z
dc.date2016-10-25T18:03:46Z
dc.date2014-05-20T15:28:40Z
dc.date2016-10-25T18:03:46Z
dc.date2001-03-01
dc.date.accessioned2017-04-06T00:08:20Z
dc.date.available2017-04-06T00:08:20Z
dc.identifierEuropean Journal of Cardio-thoracic Surgery. Amsterdam: Elsevier B.V., v. 19, n. 3, p. 321-325, 2001.
dc.identifier1010-7940
dc.identifierhttp://hdl.handle.net/11449/38425
dc.identifierhttp://acervodigital.unesp.br/handle/11449/38425
dc.identifier10.1016/S1010-7940(00)00658-8
dc.identifierWOS:000167870300019
dc.identifierhttp://dx.doi.org/10.1016/S1010-7940(00)00658-8
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/881541
dc.descriptionObjective: Nitroxides have strong antioxidant capacity but their effectiveness is limited by their rapid intracellular inactivation. Poly nitroxyl-Albumin (PNA) is capable of regenerating inactivated nitroxide. We tested the effect of PNA against reperfusion injury in heart transplantation. Methods: Pig hearts were transplanted orthotopically. In the control group (n = 9) reperfusion was performed without reperfusion modifications. In the experimental group (n = 10) 1 ml/kg PNA was given before cross-clamp release. Results: Hemodynamic performance was impaired after transplantation in both groups without significant intergroup differences. Plasma malonedialdehyde levels were significantly diminished in the PNA group as compared to the controls. CK-MB levels in both groups were increased within the first 2 h of reperfusion without significant intergroup differences. In contrast, there were found significant higher values of myocardial specific lactate dehydrogenase (LD1) in the controls versus PNA group. Conclusions: PNA was able to reduce lipid peroxidation and attenuate free radical activity. Contractile dysfunction could no be improved, indicating that (a) the radical scavenging effect was to weak or (b) other mechanisms than free oxygen radicals are responsible for myocardial damage in this experimental model. (C) 2001 Elsevier B.V. B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationEuropean Journal of Cardio-thoracic Surgery
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectreperfusion injury
dc.subjectheart transplantation
dc.subjectfree radical scavenger
dc.subjectpolynitroxyl-albumin
dc.titleInvestigations on the new free radical scavenger polynitroxyl-albumin to prevent ischemia and reperfusion injury after orthotopic heart transplantation in the pig model
dc.typeOtro


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