PARTICIPATION OF MACROPHAGES IN CHLORAMPHENICOL-POTENTIATED CARRAGEENAN-INDUCED PERITONITIS IN RATS

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMoraes, JRE
dc.creatorMoraes, F. R.
dc.creatorBechara, G. H.
dc.date2014-05-20T15:28:20Z
dc.date2016-10-25T18:03:20Z
dc.date2014-05-20T15:28:20Z
dc.date2016-10-25T18:03:20Z
dc.date1993-05-01
dc.date.accessioned2017-04-06T00:06:34Z
dc.date.available2017-04-06T00:06:34Z
dc.identifierBrazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 26, n. 5, p. 497-507, 1993.
dc.identifier0100-879X
dc.identifierhttp://hdl.handle.net/11449/38151
dc.identifierhttp://acervodigital.unesp.br/handle/11449/38151
dc.identifierWOS:A1993LC79000007
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/881317
dc.description1. We investigated the possible potentiating effect of chloramphenicol succinate (30 mg/kg, every 12 h for 4 days, ip) on the response of polymorphonuclear neutrophils to carrageenin (150 mug, ip) or dextran (100 mug, ip) in the peritoneal cavity of male Wistar rats (180-230 g; N = 12 in each group).2. Chloramphenicol potentiated the cell migration induced by carrageenin (35%) but not that induced by dextran. Previous macrophage depletion in the peritoneal cavity by washing with sterile saline abolished the cell response, whereas a previous thioglycollate-induced increase in macrophage numbers enhanced the potentiating effect (60%).3. These results suggest that the potentiating effect on polymorphonuclear neutrophil migration induced by chloramphenicol may be related to chemotactic factors released by macrophages.
dc.languageeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCHLORAMPHENICOL
dc.subjectMACROPHAGE
dc.subjectCARRAGEENAN
dc.subjectInflammation
dc.subjectPOLYMORPHONUCLEAR NEUTROPHILS
dc.titlePARTICIPATION OF MACROPHAGES IN CHLORAMPHENICOL-POTENTIATED CARRAGEENAN-INDUCED PERITONITIS IN RATS
dc.typeOtro


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