ALPHA-ADRENERGIC PATHWAYS IN THE LATERAL HYPOTHALAMUS ARE IMPORTANT FOR THE DIPSOGENIC EFFECT OF CARBACHOL INJECTED INTO THE MEDIAL SEPTAL AREA

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCallera, J. C.
dc.creatorSaad, W. A.
dc.creatorCamargo, LAA
dc.creatorMenani, José Vanderlei
dc.creatorRenzi, Antonio
dc.creatorAbraosaad, W.
dc.date2014-05-20T15:28:20Z
dc.date2016-10-25T18:03:19Z
dc.date2014-05-20T15:28:20Z
dc.date2016-10-25T18:03:19Z
dc.date1995-02-01
dc.date.accessioned2017-04-06T00:06:32Z
dc.date.available2017-04-06T00:06:32Z
dc.identifierBrazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 28, n. 2, p. 240-245, 1995.
dc.identifier0100-879X
dc.identifierhttp://hdl.handle.net/11449/38145
dc.identifierhttp://acervodigital.unesp.br/handle/11449/38145
dc.identifierWOS:A1995QQ60500015
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/881312
dc.descriptionWe studied the effect of the alpha(1)- and alpha(2)-adrenergic receptors of the lateral hypothalamus (LH) on the control of water intake induced by injection of carbachol into the medial septal area (MSA) of adult male Holtzman rats (250-300 g) implanted with chronic stainless steel cannulae into the LH and MSA. The volume of injection was always 1 mu l and was injected over a period of 30-60 s. For control, 0.15 M NaCl was used. Clonidine (20 nmol) but not phenylephrine (160 nmol) injected into the LH inhibited water intake induced by injection of carbachol (2 nmol) into the MSA, from 5.4 +/- 1.2 ml/h to 0.3 +/- 0.1 and 3.0 +/- 0.9 ml/h, respectively (N = 26). When we injected yohimbine (80 nmol) + clonidine (20 nmol) and prazosin (40 nmol) + clonidine (20 nmol) into theLH, water intake induced by injection of carbachol into the MSA was inhibited from 5.4 +/- 1.2 ml/h to 0.8 +/- 0.5 and 0.3 +/- 0.2 ml/h, respectively (N = 19). Water intake induced by carbachol (2 nmol) injected into the MSA was decreased by previous injection of yohimbine (80 nmol) + phenylephrine (160 nmol) and prazosin (40 nmol) + phenylephrine (l60 nmol) from 5.4 +/- 1.2 ml/h to 1.0 +/- 0.7 and 1.8 +/- 0.8 ml/h, respectively (N = 16). The cannula reached both the medial septal area in its medial portion and the lateral hypothalamus. It has been suggested that the different pathways for induction of drinking converge on a final common pathway. Thus, adrenergic stimulation of alpha(2),-adrenoceptors ofLH can influence this final common pathway.
dc.languageeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLATERAL HYPOTHALAMUS
dc.subjectSEPTAL AREA
dc.subjectA(1)- AND A(2)-ADRENOCEPTORS
dc.subjectCHOLINERGIC RECEPTORS
dc.subjectWATER INTAKE
dc.titleALPHA-ADRENERGIC PATHWAYS IN THE LATERAL HYPOTHALAMUS ARE IMPORTANT FOR THE DIPSOGENIC EFFECT OF CARBACHOL INJECTED INTO THE MEDIAL SEPTAL AREA
dc.typeOtro


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