The STR polymorphism (AAAAT)n within the intron 1 of the tumor protein 53 (TP53) locus in 17 populations of different ethnic groups of Africa, America, Asia and Europe

dc.creatorAzofeifa,Jorge
dc.creatorHahn,Meinhard
dc.creatorRuiz,Edward
dc.creatorHummerich,Lars
dc.creatorMorales,Ana I
dc.creatorJiménez,Gerardo
dc.creatorBarrantes,Ramiro
dc.date2004-09-01
dc.date.accessioned2023-09-25T14:01:00Z
dc.date.available2023-09-25T14:01:00Z
dc.identifierhttp://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S0034-77442004000300026
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8810544
dc.descriptionThe STR (AAAAT)n within intron 1 of the TP53 locus was screened in 17 populations from 3 main ethnic groups: Europeans, Asiatics, and Africans, and from the hybrid population of Costa Rica (1968 samples). Three alleles, 126/7 (bp/copies of the repeat), 131/8 and 136/9 were the most prevalent in all populations. Other alleles rarely reached frequencies of 10% or higher. Observed heterozygosities ranged between 0.351 and 0.829. Patterns of diversity fit well with both the geographic origin of the samples and the history of the populations screened. A statistical test suggests that single-step mutational events have been the main mechanism producing new alleles at this locus. Fixation indexes (R ST ) for this marker showed an effect of population subdivision on divergence only within the Asiatic group; they were insensitive at the level of major ethnic groups as well as within Africans and within Europeans. Rev. Biol. Trop. 52(3): 645-657. Epub 2004 Dic 15.
dc.formattext/html
dc.languageen
dc.publisherUniversidad de Costa Rica
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceRevista de Biología Tropical v.52 n.3 2004
dc.subjectpopulation genetics
dc.subjectmicrosatellite polymorphism
dc.subjectEuropeans
dc.subjectAsiatics
dc.subjectsub-Saharan Africans
dc.titleThe STR polymorphism (AAAAT)n within the intron 1 of the tumor protein 53 (TP53) locus in 17 populations of different ethnic groups of Africa, America, Asia and Europe
dc.typeinfo:eu-repo/semantics/article


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