dc.creator | Azofeifa,Jorge | |
dc.creator | Hahn,Meinhard | |
dc.creator | Ruiz,Edward | |
dc.creator | Hummerich,Lars | |
dc.creator | Morales,Ana I | |
dc.creator | Jiménez,Gerardo | |
dc.creator | Barrantes,Ramiro | |
dc.date | 2004-09-01 | |
dc.date.accessioned | 2023-09-25T14:01:00Z | |
dc.date.available | 2023-09-25T14:01:00Z | |
dc.identifier | http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S0034-77442004000300026 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8810544 | |
dc.description | The STR (AAAAT)n within intron 1 of the TP53 locus was screened in 17 populations from 3 main ethnic groups: Europeans, Asiatics, and Africans, and from the hybrid population of Costa Rica (1968 samples). Three alleles, 126/7 (bp/copies of the repeat), 131/8 and 136/9 were the most prevalent in all populations. Other alleles rarely reached frequencies of 10% or higher. Observed heterozygosities ranged between 0.351 and 0.829. Patterns of diversity fit well with both the geographic origin of the samples and the history of the populations screened. A statistical test suggests that single-step mutational events have been the main mechanism producing new alleles at this locus. Fixation indexes (R ST ) for this marker showed an effect of population subdivision on divergence only within the Asiatic group; they were insensitive at the level of major ethnic groups as well as within Africans and within Europeans. Rev. Biol. Trop. 52(3): 645-657. Epub 2004 Dic 15. | |
dc.format | text/html | |
dc.language | en | |
dc.publisher | Universidad de Costa Rica | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.source | Revista de Biología Tropical v.52 n.3 2004 | |
dc.subject | population genetics | |
dc.subject | microsatellite polymorphism | |
dc.subject | Europeans | |
dc.subject | Asiatics | |
dc.subject | sub-Saharan Africans | |
dc.title | The STR polymorphism (AAAAT)n within the intron 1 of the tumor protein 53 (TP53) locus in 17 populations of different ethnic groups of Africa, America, Asia and Europe | |
dc.type | info:eu-repo/semantics/article | |