EFFECT OF MACROPHAGE BLOCKADE ON THE RESISTANCE OF INBRED MICE TO PARACOCCIDIOIDES-BRASILIENSIS INFECTION

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorKashino, S. S.
dc.creatorFazioli, R. D.
dc.creatorMoscardibacchi, M.
dc.creatorFranco, M.
dc.creatorSingervermes, L. M.
dc.creatorBurger, E.
dc.creatorCalich, VLG
dc.date2014-05-20T15:27:52Z
dc.date2016-10-25T18:02:49Z
dc.date2014-05-20T15:27:52Z
dc.date2016-10-25T18:02:49Z
dc.date1995-06-01
dc.date.accessioned2017-04-06T00:04:25Z
dc.date.available2017-04-06T00:04:25Z
dc.identifierMycopathologia. Dordrecht: Kluwer Academic Publ, v. 130, n. 3, p. 131-140, 1995.
dc.identifier0301-486X
dc.identifierhttp://hdl.handle.net/11449/37795
dc.identifierhttp://acervodigital.unesp.br/handle/11449/37795
dc.identifier10.1007/BF01103095
dc.identifierWOS:A1995RW02800002
dc.identifierhttp://dx.doi.org/10.1007/BF01103095
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/881039
dc.descriptionThe effect of macrophage blockade on the natural resistance and on the adaptative immune response of susceptible (B10.D2/oSn) and resistant (A/Sn) mice to Paracoccidioides brasiliensis infection was investigated. B10.D2/oSn and A/Sn mice previously injected with colloidal carbon were infected ip with yeast cells to determine the 50% lethal dose, and to evaluate the anatomy and histopathology, macrophage activation, antibody production and DTH reactions. Macrophage blockade rendered both resistant and susceptible mice considerably more susceptible to infection, as evidenced by increased mortality and many disseminated lesions. P. brasiliensis infection and/or carbon treatment increased the ability of macrophages from resistant mice to spread up to 25 days after treatment. In susceptible mice the enhanced spreading capacity induced by carbon treatment was impaired at ail assayed periods except at 1 week after infection. Macrophage blockade enhanced DTH reactions in resistant mice, but did not alter these reactions in susceptible mice, which remained anergic. To the contrary, macrophage blockade enhanced specific antibody production by susceptible mice, but did nor affect the low levels produced by resistant mice. The effect of macrophage blockade confirms the natural tendency of resistant animals to mount DTH reactions in the course of the disease and the preferential antibody response developed by susceptible mice after P. brasiliensis infection. on the whole, macrophage functions appear to play a fundamental role in the natural and acquired resistance mechanisms to P. brasiliensis infection.
dc.languageeng
dc.publisherKluwer Academic Publ
dc.relationMycopathologia
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDTH REACTIONS
dc.subjectMACROPHAGE BLOCKADE
dc.subjectPARACOCCIDIOIDOMYCOSIS
dc.subjectPATHOGENICITY
dc.subjectSPECIFIC ANTIBODIES
dc.titleEFFECT OF MACROPHAGE BLOCKADE ON THE RESISTANCE OF INBRED MICE TO PARACOCCIDIOIDES-BRASILIENSIS INFECTION
dc.typeOtro


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