An Exploratory Analysis on Drug Target Locality

dc.contributorUniversidad Católica "Nuestra Señora de la Asunción" (PY)
dc.contributorUniversity of London (UK)
dc.creatorCáceres Silva, Juan José
dc.creatorPaccanaro, Alberto
dc.date2022-04-21T02:23:58Z
dc.date2022-04-21T02:23:58Z
dc.date2017
dc.date.accessioned2023-09-25T13:30:23Z
dc.date.available2023-09-25T13:30:23Z
dc.identifierhttp://hdl.handle.net/20.500.14066/2998
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8806716
dc.descriptionIn this paper we perform an exploratory analysis of the genotypic and genotypic relation between drugs and heritable diseases. Since drugs and diseases are a priori incomparable sets, we propose a drug-disease category mapping, to define an intended objective of drug design. We establish metrics such as the locality and functional similarity of drug targets, to quantify their specificity and possible side effects. The locality of drug targets can be used to analyse the physical mechanism of action drugs use to treat diseases. On the other hand, functional similarity of drug targets reveals functions that can be exploited for drug repursosing.
dc.descriptionCONACYT – Consejo Nacional de Ciencia y Tecnología
dc.descriptionPROCIENCIA
dc.languageeng
dc.relation14-INV-088
dc.rightsopen access
dc.subject6 Producción y tecnología industrial
dc.subjectDRUG TARGETS
dc.subjectPROTEIN-PROTEIN INTERACTION NETWORK
dc.subjectFARMACOLOGIA
dc.titleAn Exploratory Analysis on Drug Target Locality
dc.typeresearch article


Este ítem pertenece a la siguiente institución