dc.contributor | Universidade Estadual Paulista (UNESP) | |
dc.creator | Novelli, ELB | |
dc.creator | Rodrigues, N. L. | |
dc.creator | Ribas, B. O. | |
dc.date | 2014-05-20T15:26:29Z | |
dc.date | 2016-10-25T18:01:07Z | |
dc.date | 2014-05-20T15:26:29Z | |
dc.date | 2016-10-25T18:01:07Z | |
dc.date | 1995-03-01 | |
dc.date.accessioned | 2017-04-05T23:57:20Z | |
dc.date.available | 2017-04-05T23:57:20Z | |
dc.identifier | Human & Experimental Toxicology. Basingstoke: Stockton Press, v. 14, n. 3, p. 248-251, 1995. | |
dc.identifier | 0144-5952 | |
dc.identifier | http://hdl.handle.net/11449/36647 | |
dc.identifier | http://acervodigital.unesp.br/handle/11449/36647 | |
dc.identifier | 10.1177/096032719501400303 | |
dc.identifier | WOS:A1995QQ39500004 | |
dc.identifier | http://dx.doi.org/10.1177/096032719501400303 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/880130 | |
dc.description | Three nickel compounds were tested for pancreatic, hepatic and osteogenic damage in rats by a single i.m. injection Ni++ (7 mg kg(-1)). The nickel induced biochemical alterations included significantly increased levels of serum alkaline phosphatase in rats with NiS (75%) and NiO (50%). Amylase and aspartate transaminase were also increased, and lipoperoxide was increased in rats with NiO (5.6-fold) and NiS (3.4-fold). No serum changes were observed with NiCl2. Daily injection of Cu-Zn superoxide dismutase (SOD) conjugated with polyethylene glycol prevented the serum level changes, indicating that superoxide radical is an important intermediate in toxicity of nickel insoluble compounds. | |
dc.language | eng | |
dc.publisher | Stockton Press | |
dc.relation | Human & Experimental Toxicology | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | NICKEL | |
dc.subject | SUPEROXIDE RADICAL | |
dc.subject | TOXICITY | |
dc.subject | SUPEROXIDE DISMUTASE | |
dc.subject | RATS | |
dc.title | SUPEROXIDE RADICAL AND TOXICITY OF ENVIRONMENTAL NICKEL EXPOSURE | |
dc.type | Otro | |