Zinc supplementation does not inhibit basal and metoclopramide-stimulated prolactinemia secretion in healthy men

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCastro, AVB
dc.creatorMendonca, B. B.
dc.creatorBloise, W.
dc.creatorShuhama, T.
dc.creatorBrandao-Neto, J.
dc.date2014-05-20T15:25:30Z
dc.date2016-10-25T18:00:00Z
dc.date2014-05-20T15:25:30Z
dc.date2016-10-25T18:00:00Z
dc.date2002-01-01
dc.date.accessioned2017-04-05T23:52:44Z
dc.date.available2017-04-05T23:52:44Z
dc.identifierJournal of Trace Elements In Medicine and Biology. Jena: Urban & Fischer Verlag, v. 16, n. 2, p. 69-73, 2002.
dc.identifier0946-672X
dc.identifierhttp://hdl.handle.net/11449/35919
dc.identifierhttp://acervodigital.unesp.br/handle/11449/35919
dc.identifier10.1016/S0946-672X(02)80031-1
dc.identifierWOS:000177406700001
dc.identifierhttp://dx.doi.org/10.1016/S0946-672X(02)80031-1
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/879537
dc.descriptionDopamine (DA) and zinc (Zn++) share common mechanisms in their inhibition of prolactin (PRL) secretion. Both substances are present in the same brain areas, where Zn++ is released together with DA, suggesting a modulatory effect of Zn++ on dopaminergic receptors. The aim of the present study was to evaluate the effect of Zn supplementation on basal and PRL secretion stimulated by metoclopramide (MCP), a dopaminergic antagonist. Seven healthy men were evaluated in controlled study, where MCP (5 mg) was given intravenously, before and after 3 months of oral Zn++ (25 mg) administration. Our results indicate that chronic Zn++ administration does not change basal or MCP-stimulated plasma PRL secretion suggesting that, in humans, Zn++ does not interfere on PRL secretion mediated through dopaminergic receptors.
dc.languageeng
dc.publisherUrban & Fischer Verlag
dc.relationJournal of Trace Elements In Medicine and Biology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectzinc supplementation
dc.subjectprolactin secretion
dc.subjectmetoclopramide
dc.subjecthealthy men
dc.titleZinc supplementation does not inhibit basal and metoclopramide-stimulated prolactinemia secretion in healthy men
dc.typeOtro


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