| dc.contributor | Universidade Estadual Paulista (UNESP) | |
| dc.creator | van Haeften, T. W. | |
| dc.creator | Pimenta, W. | |
| dc.creator | Mitrakou, A. | |
| dc.creator | Korytkowski, M. | |
| dc.creator | Jenssen, T. | |
| dc.creator | Yki-Jarvinen, H. | |
| dc.creator | Gerich, J. E. | |
| dc.date | 2014-05-20T15:25:24Z | |
| dc.date | 2016-10-25T17:59:52Z | |
| dc.date | 2014-05-20T15:25:24Z | |
| dc.date | 2016-10-25T17:59:52Z | |
| dc.date | 2000-10-01 | |
| dc.date.accessioned | 2017-04-05T23:52:12Z | |
| dc.date.available | 2017-04-05T23:52:12Z | |
| dc.identifier | Metabolism-clinical and Experimental. Philadelphia: W B Saunders Co, v. 49, n. 10, p. 1318-1325, 2000. | |
| dc.identifier | 0026-0495 | |
| dc.identifier | http://hdl.handle.net/11449/35833 | |
| dc.identifier | http://acervodigital.unesp.br/handle/11449/35833 | |
| dc.identifier | 10.1053/meta.2000.9526 | |
| dc.identifier | WOS:000089861800013 | |
| dc.identifier | http://dx.doi.org/10.1053/meta.2000.9526 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/879473 | |
| dc.description | We performed hyperglycemic clamps in 283 nondiabetic Caucasians and, with multiple linear regression, determined the contribution of beta-cell function and tissue insulin sensitivity to variations in glycemia and insulinemia during oral glucose tolerance tests (OGTTs). Impaired glucose tolerance (IGT) subjects had reduced insulin sensitivity(P < .02) and beta-cell function (P < .0001). Normal glucose tolerance (NGT) subjects with first-degree type 2 diabetic relatives had reduced first and second phase insulin secretion (both, P < .05), but normal insulin sensitivity(P = .37). beta-Cell function and insulin sensitivity accounted for one fourth of the variability in glucose tolerance. Fasting plasma glucose in subjects with NGT (n = 185) was a function of both phases of insulin secretion and of insulin sensitivity tall, P < .05), whereas, in IGT subjects (n = 98), it was a function of first phase insulin secretion and insulin sensitivity(P < .01). Two-hour glycemia was a function of second phase secretion and insulin sensitivity (P < .01). Fasting and 2-hour plasma insulin levels were determined by insulin sensitivity land glycemia) in NGT subjects (P < .001), but by second phase secretion in IGT (P < .001). We conclude that beta-cell function is reduced in subjects with IGT; glycemia and insulinemia are not regulated by the same mechanisms in IGT and NGT; insulin sensitivity does not contribute to insulinemia in IGT; family history of diabetes influences beta-cell function, but not insulin sensitivity in Caucasians. Copyright (C) 2000 by W.B. Saunders Company. | |
| dc.language | eng | |
| dc.publisher | W B Saunders Co | |
| dc.relation | Metabolism-clinical and Experimental | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.title | Relative contributions of beta-cell function and tissue insulin sensitivity to fasting and postglucose-load glycemia | |
| dc.type | Otro | |
