Identification of serologic markers for school-aged children with congenital rubella syndrome

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorHyde, Terri B
dc.creatorSato, Helena Keico
dc.creatorHao, Li Juan
dc.creatorFlannery, Brendan
dc.creatorZheng, Qi
dc.creatorWannemuehler, Kathleen
dc.creatorCiccone, Flavia Helena
dc.creatorWeckx, Lily Yin
dc.creatorSáfadi, Marco Aurelio
dc.creatorMoraes, Eliane de Oliveira
dc.creatorPinhata, Marisa Mussi
dc.creatorOlbrich Neto, Jaime [UNESP]
dc.creatorBevilacqua, Maria Cecilia
dc.creatorTabith Junior, Alfredo
dc.creatorMonteiro, Tatiana Alves
dc.creatorFigueiredo, Cristina Adelaide
dc.creatorAndrus, Jon K.
dc.creatorReef, Susan E.
dc.creatorToscano, Cristiana M.
dc.creatorCastillo-Solorzano, Carlos
dc.creatorIcenogle, Joseph P.
dc.date2016-07-07T12:36:49Z
dc.date2016-07-07T12:36:49Z
dc.date2014
dc.date.accessioned2023-09-12T10:24:13Z
dc.date.available2023-09-12T10:24:13Z
dc.identifierhttp://dx.doi.org/10.1093/infdis/jiu604
dc.identifierThe Journal of Infectious Diseases, v. 31, n. 2014, p. 1, 2014.
dc.identifier0022-1899
dc.identifierhttp://hdl.handle.net/11449/141098
dc.identifier10.1093/infdis/jiu604
dc.identifier5090283757750819
dc.identifier5090283757750819
dc.identifier5090283757750819
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8790300
dc.descriptionBackground: Congenital rubella syndrome (CRS) case identification is challenging in older children since laboratory markers of congenital rubella infection do not persist beyond age 12 months. Methods: We enrolled children with CRS born between 1998 and 2003 and compared their immune responses to rubella virus with their mothers’ or a group of similar-aged, non-CRS children. Demographic data and sera were collected. Sera were tested for anti-rubella immunoglobulin G (IgG), IgG avidity, and IgG response to the three viral structural proteins (E1, E2, and C) reflected by immunoblot fluorescent signals. Results: We enrolled 32 children with CRS, 31 mothers, and 62 non-CRS children. Immunoblot signal strength to C and C signal/rubella-specific IgG ratio concentrations, were higher (p<0.029) and, E1 signal/rubella-specific IgG ratio concentrations were lower in CRS children (p=0.001) than their mothers. Compared with non-CRS children, CRS children had more rubella-specific IgG (p<0.001), C signal (p<0.001) and E2 signal (p=<0.001). Two classification rules for CRS children versus non-CRS children gave 100% specificity with greater than 65% sensitivity Conclusions: This study was the first to establish classification rules for identifying CRS in schoolaged children using laboratory biomarkers. These biomarkers should allow improved burden of disease estimates and monitoring of CRS control programs.
dc.descriptionUnited States Centers for Disease Control and Prevention (CDC), USA
dc.descriptionSão Paulo State Health Department, São Paulo, Brazil
dc.descriptionPan American Health Organization (PAHO), Washington, DC, USA
dc.descriptionChildren’s Institute, University Hospital, University of São Paulo (USP), São Paulo, Brazil
dc.descriptionHospital São Paulo, Federal University de São Paulo (UNIFESP), São Paulo, Brazil
dc.descriptionSchool of Medical Sciences of Santa Casa (FCMSC), São Paulo, Brazil
dc.descriptionSchool of Medical Sciences, University of São Paulo, Campinas, Brazil
dc.descriptionUniversity Hospital, University of São Paulo, Ribeirão Preto (USP/RP), Ribeirão Preto, Brazil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Pediatria, Faculdade de Medicina de Botucatu, Botucatu, Distrito de Rubião Júnior, CEP 18618-970, SP, Brasil
dc.descriptionAudiology Research Center, Hospital for Rehabilitation of Cranofacial Abnormalities, University of São Paulo (USP), Bauru, Brazil
dc.descriptionDivision of Education and Rehabilitation for Communication Disturbances (DERDIC), Catholic
dc.descriptionuniversity of São Paulo (PUCSP), São Paulo, Brazil
dc.descriptionDivision of Otorhinolaryngology, University of São Paulo Medical School (FM-USP)
dc.descriptionAdolfo Lutz Institute, São Paulo, Brazil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Pediatria, Faculdade de Medicina de Botucatu, Botucatu, Distrito de Rubião Júnior, CEP 18618-970, SP, Brasil
dc.format1-30
dc.languageeng
dc.relationThe Journal of Infectious Diseases
dc.relation5.186
dc.relation3,302
dc.rightsAcesso restrito
dc.sourceCurrículo Lattes
dc.titleIdentification of serologic markers for school-aged children with congenital rubella syndrome
dc.typeArtigo


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