Aerobic exercise recovers disuse-induced atrophy through the stimulus of the LRP130/PGC-1α complex in aged rats

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade do Oeste Paulista (UNOESTE)
dc.contributorUniversidade Norte do Paraná (UNOPAR)
dc.creatorVechetti Junior, Ivan José [UNESP]
dc.creatorBertaglia, Raquel Santilone [UNESP]
dc.creatorFernandez, Geysson Javier [UNESP]
dc.creatorPaula, Tassiana Gutierrez [UNESP]
dc.creatorSouza, Rodrigo Wagner Alves de
dc.creatorMoraes, Leonardo N. [UNESP]
dc.creatorMareco, Edson Assunção [UNESP]
dc.creatorFreitas, Carlos Eduardo Assumpção de [UNESP]
dc.creatorAguiar, Andreo Fernando
dc.creatorCarvalho, Robson Francisco [UNESP]
dc.creatorDal-Pai-Silva, Maeli [UNESP]
dc.date2016-07-07T12:36:36Z
dc.date2016-07-07T12:36:36Z
dc.date2015
dc.date.accessioned2023-09-12T10:23:10Z
dc.date.available2023-09-12T10:23:10Z
dc.identifierhttp://dx.doi.org/10.1093/gerona/glv064
dc.identifierThe Journals of Gerontology: Biological Sciences, v. 71, n. 5, p. 601-609, 2015.
dc.identifier1758-535X
dc.identifierhttp://hdl.handle.net/11449/141046
dc.identifier10.1093/gerona/glv064
dc.identifier5406518799128485
dc.identifier0000-0002-4901-7714
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8790248
dc.descriptionPhysical training has been shown to be important to the control of muscle mass during aging, through the activation of several pathways including, IGF1-AKT and PGC-1α. Also, it was demonstrated that LRP130, a component of the PGC-1α complex, is important for the PGC-1α-dependent transcription of several mitochondrial genes in vivo. To explore the role of physical training during aging, we investigated the effects on muscle recovery after short-term immobilization followed by 3 or 7 days with aerobic or resistance training. Using morphological (myofibrillar adenosine triphosphatase activity, to assess the total muscle fiber cross-sectional area (CSA) and the frequency of specific fiber types), biochemical (myosin heavy chain), and molecular analyses (quantitative real-time PCR, functional pathways analyses, and Western blot), our results indicated that after an atrophic stimulus, only animals subjected to aerobic training showed entire recovery of cross-sectional area; aerobic training reduced the ubiquitin–proteasome system components involved in muscle atrophy after 3 days of recovery, and the upregulation in PGC-1α expression enhanced the process of muscle recovery by inhibiting the FoxO pathway, with the possible involvement of LRP130. These results suggest that aerobic training enhanced the muscle regeneration process after disuse-induced atrophy in aged rats possibly through of the LRP130/PGC-1α complex by inhibiting the ubiquitin–proteasome system.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Instituto de Biociências de Botucatu (IBB), Departamento de Morfologia, Botucatu, SP, Brasil
dc.descriptionUniversidade de São Paulo (USP), Instituto de Biociências (IB), São Paulo, SP, Brasil
dc.descriptionUniversidade do Oeste Paulista (UNOESTE), Departamento de Fisioterapia, Presidente Prudente, SP, Brasil
dc.descriptionUniversidade Norte do Paraná (UNOPAR), Londrina, PR, Brasil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Instituto de Biociências de Botucatu (IBB), Departamento de Morfologia, Botucatu, SP, Brasil
dc.descriptionFAPESP: 2011/14484-4
dc.format601-609
dc.languageeng
dc.relationThe Journals of Gerontology Series A: Biological Sciences and Medical Sciences
dc.rightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectAging
dc.subjectMuscle mass
dc.subjectImmobilization
dc.subjectRecovery
dc.subjectExercise training
dc.titleAerobic exercise recovers disuse-induced atrophy through the stimulus of the LRP130/PGC-1α complex in aged rats
dc.typeArtigo


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