Frequency of the MDR1 mutant allele associated with multidrug sensitivity in dogs from Brazil

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorMississippi State University
dc.creatorMonobe, Marina Mitie [UNESP]
dc.creatorAraújo Júnior, João Pessoa [UNESP]
dc.creatorLunsford, Kari V.
dc.creatorSilva, Rodrigo da
dc.creatorBulla, Camilo
dc.date2016-07-07T12:34:27Z
dc.date2016-07-07T12:34:27Z
dc.date2015
dc.date.accessioned2023-09-12T10:14:30Z
dc.date.available2023-09-12T10:14:30Z
dc.identifierhttp://dx.doi.org/10.2147/VMRR.S72373
dc.identifierVeterinary Medicine: Research and Reports, v. 6, p. 111-117, 2015.
dc.identifier2230-2034
dc.identifierhttp://hdl.handle.net/11449/140564
dc.identifier10.2147/VMRR.S72373
dc.identifierISSN2230-2034-2015-06-111-117.pdf
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8789768
dc.descriptionTo date, a 4-bp deletion in the MDR1 gene has been detected in more than ten dog breeds, as well as in mixed breed dogs, in several countries, however information regarding this mutation in dogs from Brazil is lacking. For this reason, 103 Collies, 77 Border Collies, 76 Shetland Sheepdogs, 20 Old English Sheepdogs, 55 German Shepherds, 16 Australian Shepherds, and 53 Whippets from Brazil were screened for the presence of the mutation. The heterozygous mutated genotype, MDR1 (+/-), frequency found for Collies, Australian Shepherd, and Shetland Sheepdog was 50.5% (95% CI =41.1%–59.9%), 31.3% (95% CI =8.6%–53.2%), and 15.8% (95% CI =7.7%–23.9%), respectively. Homozygous mutated genotype, MDR1 (-/-), was detected only in Collies 35.9%. The MDR1 allele mutant frequency found for Collies, Australian Shepherd, and Shetland Sheepdog was 61.2% (95% CI =54.8%–67.5%), 15.6% (95% CI =3.1%–28.2%), and 7.9% (95% CI =3.7%–12.1%), respectively. Additionally, even free of the mutant allele, the maximum mutant prevalence (MMP) in that population, with 95% CI, was 3.8%, 5.2%, 5.4%, and 13.8% for Border Collies, German Shepherds, Whippets, and Old English Sheepdogs, respectively. In this way, this information is important, not only for MDR1 genotype-based breeding programs and international exchange of breeding animals of predisposed breeds, but also for modification of drug therapy for breeds at risk.
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Clínica Veterinária, Botucatu, SP, Brasil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Instituto de Biociências (IBB), Departamento de Microbiologia e Imunologia, Botucatu, SP, Brasil
dc.descriptionMississippi State University, MS, USA
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Clínica Veterinária, Botucatu, SP, Brasil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Instituto de Biociências (IBB), Departamento de Microbiologia e Imunologia, Botucatu, SP, Brasil
dc.format111-117
dc.languageeng
dc.relationVeterinary Medicine: Research and Reports
dc.rightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectP-glycoprotein
dc.subjectMDR1 mutation
dc.subjectIvermectin
dc.subjectDog
dc.subjectDrug sensitivity
dc.titleFrequency of the MDR1 mutant allele associated with multidrug sensitivity in dogs from Brazil
dc.typeArtigo


Este ítem pertenece a la siguiente institución