A possible increase of activity of endothelial l-arginine/nitric oxide pathway in aortas of diet-induced obesity rats

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.creatorNascimento, Thiago Bruder do
dc.creatorCampos, Dijon Henrique Salomé de
dc.creatorAlves, C. A. B.
dc.creatorCicogna, Antonio Carlos [UNESP]
dc.creatorCordellini, S.
dc.date2016-04-01T18:44:40Z
dc.date2016-04-01T18:44:40Z
dc.date2011
dc.date.accessioned2023-09-12T09:15:42Z
dc.date.available2023-09-12T09:15:42Z
dc.identifierhttp://dx.doi.org/10.4172/2161-1017.S8-001
dc.identifierEndocrinology & Metabolic Syndrome, v. 1, n. 8, p. 1-7, 2011.
dc.identifier2161-1017
dc.identifierhttp://hdl.handle.net/11449/137202
dc.identifier10.4172/2161-1017.S8-001
dc.identifierISSN2161-1017-2011-01-08-01-07.pdf
dc.identifier5616488317690037
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8786441
dc.descriptionThe obesity is associated with cardiovascular disorders. The aim of present purpose was test the hypothesis that the diet-induced obesity is able to generate a vascular adaptive response in aortic rings; this response could be mediated by NO pathway. The present work used Thirty-day-old male Wistar rats (70-100 g) were distributed into two groups: control (C) and obese (Ob). The obesity was induced through of hypercaloric diet during 15 weeks, the vascular response was assessed through different protocols of vascular reactivity studies and characterization of obesity was also evaluated. The obesity was characterized for decreased of glucose tolerance, hyperinsulinemia, hyperleptinemia and rise of adiposity index. In relation to vascular alterations, the diet-induced obesity generated decreased maximal response to noradrenaline, response which was abolished with presence of L-NAME, and increased relaxing to acetylcholine. There was no difference between groups in the blood pressure. The vascular responses observed in present work might have occurred with the aim of decrease of cardiovascular risk linked with obesity pathology; these findings suggest that obesity can be considered a paradoxical disorder.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionDepartment de Pharmacology, Scholl of Medicine of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Farmacologia, Instituto de Biociências de Botucatu, Botucatu, Distrito de Rubião Júnior, s/n, CEP 18618-000, SP, Brasil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Clínica Médica, Faculdade de Medicina (FMB), Botucatu, Distrito de Rubião Júnior, s/n, CEP 18618-000, SP, Brasil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Farmacologia, Instituto de Biociências de Botucatu, Botucatu, Distrito de Rubião Júnior, s/n, CEP 18618-000, SP, Brasil
dc.descriptionFAPESP: 2009/03771-2
dc.format1-7
dc.languageeng
dc.relationEndocrinology & Metabolic Syndrome
dc.rightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectDiet-induced obesity
dc.subjectParadoxical obesity
dc.subjectNitric oxide
dc.titleA possible increase of activity of endothelial l-arginine/nitric oxide pathway in aortas of diet-induced obesity rats
dc.typeArtigo


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