Potential endocrinedisruptor activity of drinking water samples

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Estadual de Campinas (UNICAMP)
dc.contributorUniversidade de São Paulo (USP)
dc.creatorSolano, Marize de Lourdes Marzo [UNESP]
dc.creatorRaimundo, Cassiana Carolina Montagner
dc.creatorVaccari, Carolina
dc.creatorJardim, Wilson F.
dc.creatorFranci, Janete Aparecida Anselmo
dc.creatorCarolino, Ruither de O G
dc.creatorLuvizutto, João Francisco Lozano [UNESP]
dc.creatorUmbuzeiro, Gisela Aragão
dc.creatorCamargo, João Lauro Viana de [UNESP]
dc.date2016-04-01T18:43:34Z
dc.date2016-04-01T18:43:34Z
dc.date2015
dc.date.accessioned2023-09-12T09:11:37Z
dc.date.available2023-09-12T09:11:37Z
dc.identifierhttp://dx.doi.org/10.4161/23273747.2014.983384
dc.identifierEndocrine Disruptors, v. 3, n. 1, p. e983384, 2015.
dc.identifier2327-3747
dc.identifierhttp://hdl.handle.net/11449/136966
dc.identifier10.4161/23273747.2014.983384
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8786208
dc.descriptionConventional water treatment plants (WTP) do not completely remove contaminants with endocrine activity which may then be present in drinking water (DW). The potential for endocrine disruption of 2 DW samples collected in 2010 and 2012 from a conventional WTP in São Paulo, Brazil was investigated. In vivo assays were conducted with 21-day old female rats exposed to DW extracts for 3- (uterotrophic assay) or 20-days (pubertal assay). The exposure represented a daily ingestion of 2 L, 10 L and 20 L of DW per 60 kg-body weight. Caffeine (5.8 – 21 ug/L), estrone (1 ng/L), atrazine (2.2 – 11.2 ng/L), carbendazim (0.22 ng/L), azoxystrobin (0.23 ng/L), tebuconazole (0.19 ng/L) and imidacloprid (0.88 ng/L) were detected in DW extracts by LC-MS/MS. No increase in uterus wet weight in the uterotrophic assay, and no alteration of vaginal opening in the pubertal assay were observed. However, there were increased absolute blotted uterus weights in animals treated for 3-days with the 3 doses of both DW samples. LH and FSH levels showed significant dose-response increases in the uterotrophic assay using the 2010 DW sample, in association with a significantly increased incidence of vaginal keratinization after the 3-day exposure. The pubertal animals exposed to the 2010 DW had a significant body weight gain and decreased LH at the highest dose. Results suggest that DW samples tested exerted estrogenic and hypothalamic-hypophysis activity alterations in vivo.
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Patologia, Faculdade de Medicina de Botucatu, Botucatu, Distrito de Rubião Jr., CEP 18610-000, SP, Brasil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Patologia, Faculdade de Medicina de Botucatu, Botucatu, Distrito de Rubião Jr., CEP 18610-000, SP, Brasil
dc.formate983384
dc.languageeng
dc.relationEndocrine Disruptors
dc.rightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectEmerging contaminants
dc.subjectEndocrine disruption
dc.subjectPesticides
dc.subjectPubertal female rat development
dc.subjectUterotrophic assay
dc.titlePotential endocrinedisruptor activity of drinking water samples
dc.typeArtigo


Este ítem pertenece a la siguiente institución