Piperacillin/tazobactam-induced neurotoxicity in a hemodialysis patient: a case report

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorNeves, Precil Diego Miranda de Menezes [UNESP]
dc.creatorFreitas, Fernanda Moreira de [UNESP]
dc.creatorKojima, Christiane Akemi [UNESP]
dc.creatorCarmello, Beatriz Leone [UNESP]
dc.creatorBazan, Rodrigo [UNESP]
dc.creatorBarretti, Pasqual [UNESP]
dc.creatorMartin, Luis Cuadrado [UNESP]
dc.date2016-04-01T18:42:56Z
dc.date2016-04-01T18:42:56Z
dc.date2015
dc.date.accessioned2023-09-12T09:09:40Z
dc.date.available2023-09-12T09:09:40Z
dc.identifierhttp://dx.doi.org/10.1111/hdi.12194
dc.identifierHemodialysis International, v. 19, n. 1, p. 143-145, 2015.
dc.identifier1492-7535
dc.identifierhttp://hdl.handle.net/11449/136852
dc.identifier10.1111/hdi.12194
dc.identifier7862086981190726
dc.identifier5496411983893479
dc.identifier7862086981190726
dc.identifier5496411983893479
dc.identifier7862086981190726
dc.identifier5496411983893479
dc.identifier4923203168446615
dc.identifier0000-0003-4979-4836
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8786094
dc.descriptionAntibiotics are potentially a cause of neurotoxicity in dialysis patients, the most common are thebeta-lactams as ceftazidime and cefepime, and few cases have been reported after piperacillin/tazobactam use. This report presents a case of a hypertensive and diabetic 67-year-old woman inregular hemodialysis, which previously had a stroke. She was hospitalized presenting pneumonia,which was initially treated with cefepime. Two days after treatment, she presented dysarthria, lefthemiparesis, ataxia, and IX and X cranial nerves paresis. Computed tomography showed no acutelesions and cefepime neurotoxicity was hypothesized, and the antibiotic was replaced bypiperacillin/tazobactam. The neurologic signs disappeared; however, 4 days after with piperacillin/tazobactam treatment, the neurological manifestations returned. A new computed tomographyshowed no new lesions, and the second antibiotic regimen withdrawn. After two hemodialysissessions, the patient completely recovered from neurological manifestations. The patient presentedsequentially neurotoxicity caused by two beta-lactams antibiotics. This report meant to alertclinicians that these antibiotics have dangerous neurological effects in chronic kidney diseasepatients.
dc.descriptionUniversidade Estadual Paulista, Departamento de Clínica Médica, Faculdade de Medicina de Botucatu
dc.descriptionUniversidade Estadual Paulista, Departamento de Neurologia, Psicologia e Psiquiatria, Faculdade de Medicina de Botucatu
dc.format143-145
dc.languageeng
dc.relationHemodialysis International
dc.relation1.237
dc.relation0,554
dc.rightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectChronic kidney disease
dc.subjectHemodialysis
dc.subjectNeurotoxicity
dc.subjectPiperacillin/tazobactam
dc.titlePiperacillin/tazobactam-induced neurotoxicity in a hemodialysis patient: a case report
dc.typeArtigo


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