Effect of zinc administration on thyrotropin releasing hormone-stimulated prolactinemia in healthy men

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCastro, AVB
dc.creatorMendonca, B. B.
dc.creatorBloise, W.
dc.creatorShuhama, T.
dc.creatorBrandao-Neto, J.
dc.date2014-05-20T15:23:55Z
dc.date2016-10-25T17:57:58Z
dc.date2014-05-20T15:23:55Z
dc.date2016-10-25T17:57:58Z
dc.date1999-12-01
dc.date.accessioned2017-04-05T23:44:28Z
dc.date.available2017-04-05T23:44:28Z
dc.identifierBiometals. Dordrecht: Kluwer Academic Publ, v. 12, n. 4, p. 347-352, 1999.
dc.identifier0966-0844
dc.identifierhttp://hdl.handle.net/11449/34605
dc.identifierhttp://acervodigital.unesp.br/handle/11449/34605
dc.identifier10.1023/A:1009225904221
dc.identifierWOS:000085277700009
dc.identifierhttp://dx.doi.org/10.1023/A:1009225904221
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/878495
dc.descriptionPrevious in vitro studies have demonstrated zinc (Zn++) inhibition of basal and of potassium (K+) or thyrotropin-releasing hormone (TRH)-stimulated prolactin (PRL) secretion, in a selective, reversible, and dose-dependent manner. Thus, Zn++ may regulate physiologically pituitary PRL secretion. Furthermore, studies with patients with uremia, cirrhosis or prolactinoma, have shown the coexistence of hypozincemia and hyperprolactinemia and zinc supplementation did not correct hyperprolactinemia in these patients. In normal individuals Zn++ administration produced controversial results on PRL secretion. Here, we investigated whether zinc administration affects TRH-stimulated PRL in healthy men. We found that Zn++ administration does not change the TRH-stimulated PRL. Therefore, in normal conditions, Zn++ does not inhibit TRH-stimulated prolactinemia. In addition, we found that acute increases of blood PRL and TRH do not alter blood Zn++ levels.
dc.languageeng
dc.publisherKluwer Academic Publ
dc.relationBiometals
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectzinc tolerance test
dc.subjectthyrotropin tolerance test
dc.subjectprolactin secretion
dc.subjecthealthy men
dc.titleEffect of zinc administration on thyrotropin releasing hormone-stimulated prolactinemia in healthy men
dc.typeOtro


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