Central interaction between atrial natriuretic peptide and angiotensin II in the control of sodium intake and excretion in female rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorDeAngelis, P. R.
dc.creatorAntunes, V. R.
dc.creatorCamargo, GMPA
dc.creatorSaad, W. A.
dc.creatorRenzi, Antonio
dc.creatorCamargo, LLA
dc.date2014-05-20T15:23:54Z
dc.date2016-10-25T17:57:56Z
dc.date2014-05-20T15:23:54Z
dc.date2016-10-25T17:57:56Z
dc.date1996-12-01
dc.date.accessioned2017-04-05T23:44:21Z
dc.date.available2017-04-05T23:44:21Z
dc.identifierBrazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 29, n. 12, p. 1671-1674, 1996.
dc.identifier0100-879X
dc.identifierhttp://hdl.handle.net/11449/34585
dc.identifierhttp://acervodigital.unesp.br/handle/11449/34585
dc.identifierWOS:A1996VX80700016
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/878479
dc.descriptionWe investigated the effects of estrogen on sodium intake and excretion induced by angiotensin II (ANG II), atrial natriuretic peptide (ANP) or ANG II plus ANP injected into the median preoptic nucleus (MnPO). Female Holtzman rats weighing 250-300 g were used. Sodium ingestion and excretion 120 min after the injection of 0.5 mu l of 0.15 M NaCl into the MnPO were 0.3 +/- 0.1 ml (N = 12) and 29 +/- 7 mu Eq in intact rats, 0.5 +/- 0.2 ml (N = 10) and 27 +/- 6 mu Eq in ovariectomized rats, and 0.2 +/- 0.08 (N = 11) and 38 +/- 8 mu Eq in estrogen-treated ovariectomized (50 mu g/day for 21 days) rats, respectively. ANG II (21 mu M) injection in intact, ovariectomized, and estrogen-treated ovariectomized rats increased sodium intake (3.8 +/- 0.4, 1.8 +/- 0.3 and 1.2 +/- 0.2 ml/120 min, respectively) (N = 11) and increased sodium excretion (166 +/- 18, 82 +/- 22 and 86 +/- 12 mu Eq/120 min, respectively) (N = 11). ANP (65 mu M) injection in intact (N = 11), ovariectomized(N = 10)and estrogen-treated ovariectomized (N = 10) rats increased sodium intake (1.4 +/- 0.2, 1.8 +/- 0.3, and 1.7 +/- 0.3 ml/120 min, respectively) and sodium excretion (178 +/- 19, 187 +/- 9, and 232 +/- 29 mu Eq/120 min, respectively). Concomitant injection of ANG II and ANP into the MnPO of intact (N = 12), ovariectomized (N = 10) and estrogentreated ovariectomized (N = 10) rats caused smaller effects than those produced by each peptide given alone: 1.3 +/- 0.2, 0.9 +/- 0.2 and 0.3 +/- 0.1 ml/120 min for sodium intake, respectively, and 86 +/- 9, 58 +/- 7, and 22 +/- 4 mu Eq/120 min for sodium excretion, respectively. Taken together, these results demonstrate that there is an antagonistic interaction of ANP and ANG II on sodium intake and excretion, and that reproductive hormones affect this interaction.
dc.languageeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectatrial natriuretic peptide
dc.subjectangiotensin II
dc.subjectovariectomy
dc.subjectsodium intake
dc.subjectsodium excretion
dc.titleCentral interaction between atrial natriuretic peptide and angiotensin II in the control of sodium intake and excretion in female rats
dc.typeOtro


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