Development and in vitro skin delivery of dexamethasone acetate-loaded surfactant-based systems

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorUrban, Maria Cristina Cocenza
dc.creatorLandgraf, Daniele S
dc.creatorOyafuso, Marcia Helena
dc.creatorChiavacci, Leila Aparecida
dc.creatorSarmento, Victor Hugo Vitorino
dc.creatorChorilli, Marlus [UNESP]
dc.creatorCorrêa, Marcos Antonio
dc.creatorGremião, Maria Palmira Daflon [UNESP]
dc.date2016-01-28T16:56:41Z
dc.date2016-01-28T16:56:41Z
dc.date2013
dc.date.accessioned2023-09-12T08:17:02Z
dc.date.available2023-09-12T08:17:02Z
dc.identifierhttp://dx.doi.org/10.1166/jnd.2013.1024
dc.identifierJournal of Nanopharmaceutics and Drug Delivery, v. 1, p. 323-334, 2013.
dc.identifier2167-9312
dc.identifierhttp://hdl.handle.net/11449/133806
dc.identifier10.1166/jnd.2013.1024
dc.identifier9058616548785516
dc.identifier2008100603446246
dc.identifier9129780536724256
dc.identifier3316011688829943
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8783058
dc.descriptionTopical corticosteroids, e.g., dexamethasone acetate (DMA), are extensively used to treat cutaneous inflammatory disorders even though their use is correlated with potential local and systemic side effects. The objective of this study was to develop and test the topical delivery of DMA-loaded surfactant based systems in vitro; these studies could guarantee a suitable delivery and therapeutic efficacy, as well as minimize DMA's side effects. A phase diagram was constructed using polyoxypropylene (5) polyoxyethylene (20) cetyl alcohol as the surfactant (S), isopropyl myristate as the oil phase (O) and water (W). The systems were characterized using polarization light microscopy (PLM), as well as rheological and small angle X-ray scattering (SAXS) measurements. Depending on the concentration of the constituents, it was possible to obtain microemulsions (MEs) and liquid crystalline mesophases (lamellar and hexagonal). These types of arrangement were verified using PLM measurements. The SAXS results revealed that increasing the W/S ratio led to ME, as well as lamellar (LAM) and hexagonal (HEX) arrangements. The MEs displayed typical Newtonian behavior while the LAM and HEX phases exhibited pseudoplasticity and plasticity, respectively. The MEs displayed excellent drug solubilization that was approximately 10-fold higher than was observed with the individual components. The in vitro cutaneous permeation studies using pig ear skin and analysis of the mechanical parameters (hardness, compressibility, cohesiveness and adhesiveness) were carried out with a HEX phase and O/W emulsion. The HEX phase achieved better drug permeation and retention in the skin while its mechanical properties were suitable for skin administration. PPG-5-CETETH-20-based systems may be a promising platform delivering DMA and other topical corticosteroids through the skin.
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fármacos e Médicamentos, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara - Jaú km 1, CEP 14801-902, SP, Brasil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fármacos e Médicamentos, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara - Jaú km 1, CEP 14801-902, SP, Brasil
dc.format323-334
dc.languageeng
dc.relationJournal of Nanopharmaceutics and Drug Delivery
dc.rightsAcesso restrito
dc.sourceCurrículo Lattes
dc.titleDevelopment and in vitro skin delivery of dexamethasone acetate-loaded surfactant-based systems
dc.typeArtigo


Este ítem pertenece a la siguiente institución