Comparative study over methods developed for quantification of darunavir in tablets by environmental friendly infrared and capillary electrophoretic techniques

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorKogawa, Ana Carolina [UNESP]
dc.creatorSalgado, Hérida Regina Nunes [UNESP]
dc.date2016-01-28T16:56:34Z
dc.date2016-01-28T16:56:34Z
dc.date2015
dc.date.accessioned2023-09-12T08:16:26Z
dc.date.available2023-09-12T08:16:26Z
dc.identifierhttp://www.ikpress.org/abstract/3648#.Vo_7-vkrLIU
dc.identifierJournal International Research in Medical and Pharmaceutical Sciences, v. 2, n. 3, p. 99-105, 2015.
dc.identifier2231-685X
dc.identifierhttp://hdl.handle.net/11449/133778
dc.identifier6638857912920334
dc.identifier9881720291571774
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8783030
dc.descriptionDarunavir, a protease inhibitor used in the treatment of HIV infection, presents few methods for its determination in pharmaceuticals. Infrared (IR) spectroscopy offers the possibility of obtaining spectra relatively quickly, providing interesting information, analytically, qualitatively or quantitatively. Capillary electrophoresis (CE) performs separations of high efficiency in shorter time with reagents and samples in small quantity. These two methods are cost-benefitted when we evaluate the green level and the cost of analysis. Faster and cheaper methods without generating organic waste by IR and CE for the quantification of darunavir were developed and validated, focusing socioeconomic impact of analytical decisions. If the cost of acquisition, maintenance, production, analysis and conditioning of drugs and pharmaceuticals is high, consequently the price of this product in the market will be higher and it cannot be accessible to the patient. Treatment failure not only affects the quality of life of patients, but also contributes significantly to the economic burden of the health system. In this context there is a tool called Analysis of the Life Cycle, which comes to make us think in a multidimensional way focusing the whole, the parts and especially the interaction among the parts of a system.
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fármacos e Médicamentos, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jaú, km1, Campus, CEP 14801-902, SP, Brasil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fármacos e Médicamentos, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jaú, km1, Campus, CEP 14801-902, SP, Brasil
dc.format99-105
dc.languageeng
dc.relationJournal International Research in Medical and Pharmaceutical Sciences
dc.rightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectCapillary electrophoresis
dc.subjectDarunavir
dc.subjectEnvironmental friendly
dc.subjectGreen chemistry
dc.subjectInfrared spectroscopy
dc.subjectSocioeconomic impact
dc.titleComparative study over methods developed for quantification of darunavir in tablets by environmental friendly infrared and capillary electrophoretic techniques
dc.typeArtigo


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