Anti-inflammatory drug design by molecular hybridization approach

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorBosquesi, Priscila Longhin [UNESP]
dc.creatorMelo, Tais Regina Ferreira [UNESP]
dc.creatorVizioli, Ednir de Oliveira [UNESP]
dc.creatorSantos, Jean Leandro dos [UNESP]
dc.creatorChung, Man Chin [UNESP]
dc.date2016-01-28T16:56:31Z
dc.date2016-01-28T16:56:31Z
dc.date2011
dc.date.accessioned2023-09-12T08:16:09Z
dc.date.available2023-09-12T08:16:09Z
dc.identifierhttp://dx.doi.org/10.3390/ph4111450
dc.identifierPharmaceuticals, v. 4, p. 1450-1474, 2011.
dc.identifier1424-8247
dc.identifierhttp://hdl.handle.net/11449/133761
dc.identifier10.3390/ph4111450
dc.identifierISSN1424-8247-2011-04-1450-1474.pdf
dc.identifier4083068210623663
dc.identifier3204277043366119
dc.identifier5435899068903487
dc.identifier9734333607975413
dc.identifier5737933639516944
dc.identifier0000-0003-4141-0455
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8783013
dc.descriptionThe design of new drugs with better physiochemical properties, adequateabsorption, distribution, metabolism, and excretion, effective pharmacologic potency andlacking toxicity remains is a challenge. Inflammation is the initial trigger of severaldifferent diseases, such as Alzheimer s disease, asthma, atherosclerosis, colitis, rheumatoidarthritis, depression, cancer; and disorders such as obesity and sexual dysfunction.Although inflammation is not the direct cause of these disorders, inflammatory processesoften increase related pain and suffering. New anti-inflammatory drugs developed usingmolecular hybridization techniques to obtain multiple-ligand drugs can act at one or multipletargets, allowing for synergic action and minimizing toxicity. This work is a review of newanti-inflammatory drugs developed using the molecular modification approach.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Pesquisa (CNPq)
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Ciências Farmacêuticas de Araraquara (FCFAR), Departamento de Fármacos e Medicamentos, Rodovia Araraquara-Jaú, km 1, Campus Ville, CEP 14801902, Araraquara, SP, Brasil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Ciências Farmacêuticas de Araraquara (FCFAR), Departamento de Fármacos e Medicamentos, Rodovia Araraquara-Jaú, km 1, Campus Ville, CEP 14801902, Araraquara, SP, Brasil
dc.descriptionFAPESP: 2010/12495-6
dc.descriptionFAPESP: 2010/50330-9
dc.descriptionCNPq: 308157/2010-9
dc.format1450-1474
dc.languageeng
dc.relationPharmaceuticals
dc.relation1,293
dc.rightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectAnti-inflammatory
dc.subjectHybridization
dc.subjectMultiple-ligands
dc.subjectMutual prodrug
dc.titleAnti-inflammatory drug design by molecular hybridization approach
dc.typeArtigo


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