Acute and subchronic antihyperglycemic activities of bowdichia virgilioides roots in non diabetic and diabetic rats

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal do Paraná (UFPR)
dc.contributorUniversidade Federal de Mato Grosso (UFMT)
dc.creatorSilva, Ana
dc.creatorSantos, Masa
dc.creatorSantos, Maísa Pavani dos
dc.creatorFrança, Sulem Aparecida de
dc.creatorSilva, Virgnia Claudia da
dc.creatorSilva, Luiz Everson da
dc.creatorFigueiredo, Uir Santana de
dc.creatorDall'Oglio, Evandro Luiz
dc.creatorSousa Júnior, Paulo Teixeira de
dc.creatorLopes, Carbene França
dc.creatorBaviera, Amanda Martins [UNESP]
dc.creatorKawashita, Nair Honda
dc.date2016-01-28T16:56:14Z
dc.date2016-01-28T16:56:14Z
dc.date2015
dc.date.accessioned2023-09-12T08:15:05Z
dc.date.available2023-09-12T08:15:05Z
dc.identifierhttp://dx.doi.org/10.5455/jice.20141028022407
dc.identifierJournal of Intercultural Ethnopharmacology, v. 4, n. 1, p. 57-63, 2015.
dc.identifier2146-8397
dc.identifierhttp://hdl.handle.net/11449/133701
dc.identifier10.5455/jice.20141028022407
dc.identifierISSN2146-8397-2015-04-01-57-63.pdf
dc.identifier3736475025187750
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8782955
dc.descriptionAim: The present study was undertaken to evaluate the acute and subchronic antihyperglycemic effects of methanolic extract of B. virgilioides root bark of B. virgilioides in streptozotocin-induced diabetic rats.Materials and Methods: The extract (100, 250 or 500 mg/kg) was orally administered to male Wistar diabetic (streptozotocin, 42 mg/kg i.v.) and non-diabetic rats into two main protocols: i) subchronic experiments, where animals were treated for 21 days with B. virgilioides extract and the following parameters were evaluated: body weight, fluid and food intake (determined daily), urinary glucose and urea (every 3 days) and glycemia (every 5 days). At the end of the experimental period, skeletal muscles (extensor digitorum longus and soleus), retroperitoneal and epididymal white adipose tissues were collected and weighed; liver samples were used for the determination of the lipid and glycogen contents; ii) acute experiments, which evaluated the alterations on fasting and post-prandial glycemia and on glucose tolerance using the oral glucose tolerance test (OGTT).Results: In subchronic experiments, the treatment with B. virgilioides extract did not change any parameter evaluated in diabetic and non-diabetic animals. On fasting and post-prandial glycemia, the extract treatment did not promote changes in the glycemia values in diabetic or non-diabetic animals. In OGTT, the treatment with 500 mg/kg B. virgilioides extract reduced the hyperglycemia peak after a glucose overload, when compared with non-treated diabetic animals, resulting in a lower area under curve (AUC). Conclusion: The results of our work indicate that B. virgilioides root extract promotes an acute antihyperglycemic effect in STZ-diabetic rats; this effect probably occurs through an inhibition of the intestinal glucose absorption. The continuity of the research is necessary to elucidate these possibilities.
dc.descriptionFundação de Amparo à Pesquisa do Estado de Mato Grosso (FAPEMAT)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rua Expedicionários do Brasil, 1621, Centro, CEP 14801902, SP, Brasil
dc.descriptionDepartment of Chemistry, Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil
dc.descriptionDepartment of Science Education, Federal University of Paraná, Coastal Sector, Matinhos, Paraná, Brazil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rua Expedicionários do Brasil, 1621, Centro, CEP 14801902, SP, Brasil
dc.format57-63
dc.languageeng
dc.relationJournal of Intercultural Ethnopharmacology
dc.relation0,285
dc.rightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectFabaceae
dc.subjectBowdichia virgilioides
dc.subjectAntihyperglycemic effect
dc.subjectMedicinal plants
dc.subjectAntihyperglycemic plants
dc.titleAcute and subchronic antihyperglycemic activities of bowdichia virgilioides roots in non diabetic and diabetic rats
dc.typeArtigo


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