Coupling between respiratory and sympathetic activities as a novel mechanism underpinning neurogenic hypertension

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorMachado, Benedito Honório
dc.creatorZoccal, Daniel Breseghello [UNESP]
dc.date2016-01-28T16:55:49Z
dc.date2016-01-28T16:55:49Z
dc.date2011
dc.date.accessioned2023-09-12T08:13:20Z
dc.date.available2023-09-12T08:13:20Z
dc.identifierhttp://dx.doi.org/10.1007/s11906-011-0198-7
dc.identifierCurrent Hypertension Reports, v. 13, n. 3, p. 229-236, 2011.
dc.identifier1522-6417
dc.identifierhttp://hdl.handle.net/11449/133606
dc.identifier10.1007/s11906-011-0198-7
dc.identifier1912911113942497
dc.identifier1958567557189244
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8782860
dc.descriptionEnhanced sympathetic outflow to the heart and resistance vessels greatly contributes to the onset and maintenance of neurogenic hypertension. There is a consensus that the development of hypertension (clinical and experimental) is associated with an impairment of sympathetic reflex control by arterial baroreceptors. More recently, chronic peripheral chemoreflex activation, as observed in obstructive sleep apnea, has been proposed as another important risk factor for hypertension. In this review, we present and discuss recent experimental evidence showing that changes in the respiratory pattern, elicited by chronic intermittent hypoxia, play a key role in increasing sympathetic activity and arterial pressure in rats. This concept parallels results observed in other models of neurogenic hypertension, such as spontaneously hypertensive rats and rats with angiotensin II–salt-induced hypertension, pointing out alterations in the central coupling of respiratory and sympathetic activities as a novel mechanism underlying the development of neurogenic hypertension.
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fisiologia e Patologia, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801903, SP, Brasil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fisiologia e Patologia, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801903, SP, Brasil
dc.format229-236
dc.languageeng
dc.relationCurrent Hypertension Reports
dc.relation3.234
dc.relation1,058
dc.rightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectHypertension
dc.subjectSympathetic overactivity
dc.subjectRespiration
dc.subjectRespiratory-sympathetic coupling
dc.subjectHypoxia
dc.titleCoupling between respiratory and sympathetic activities as a novel mechanism underpinning neurogenic hypertension
dc.typeArtigo


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