TNF-alpha and IL-6 immunohistochemistry in rat renal tissue experimentaly infected with Leptospira interrogans serovar Canicola

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorMarinho, Márcia [UNESP]
dc.creatorMonteiro, Cristina Maria Rodrigues [UNESP]
dc.creatorPeiró, Juliana Regina [UNESP]
dc.creatorMachado, Gisele Fabrino [UNESP]
dc.creatorOliveira-Junior, I. S.
dc.date2013-09-30T18:25:20Z
dc.date2014-05-20T13:42:54Z
dc.date2013-09-30T18:25:20Z
dc.date2014-05-20T13:42:54Z
dc.date2008-01-01
dc.date.accessioned2023-09-12T07:49:46Z
dc.date.available2023-09-12T07:49:46Z
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992008000300012
dc.identifierJournal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 14, n. 3, p. 533-540, 2008.
dc.identifier1678-9199
dc.identifierhttp://hdl.handle.net/11449/132302
dc.identifier10.1590/S1678-91992008000300012
dc.identifierS1678-91992008000300012
dc.identifierWOS:000259279500012
dc.identifier2-s2.0-52249107118
dc.identifierS1678-91992008000300012-en.pdf
dc.identifier5071093931017493
dc.identifier6586331343354343
dc.identifier2976129874554698
dc.identifier0310405558125634
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8781580
dc.descriptionLeptospirosis is a public health problem worldwide and its etiology remains unclear. Its pathogenesis involves a complex interaction between host and infecting microorganism. The inflammatory reaction that controls the infection process also underscores many pathophysiological events occurring in leptospirosis. We investigated the presence of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in renal tissues by immunohistochemical and histopathological examination in animals experimentally inoculated with Leptospira serovar Canicola. All the tests were carried out 2, 7, 14, 21 or 28 days after inoculation. Although TNF-alpha and IL-6 had been detected in tissues throughout the observation period, these cytokines appeared more intensely during the initial phase of infection. Therefore, both TNF-alpha and IL-6 were associated with the immunopathogenesis of leptospirosis. This profile suggests a high immunocellular response throughout the early infection stages followed by subsequent humoral response.
dc.descriptionUniv Estadual Paulista, Sch Dent, FOA, Dept Anim Hlth & Prod, BR-16050680 Aracatuba, SP, Brazil
dc.descriptionUniv Estadual Paulista, Sch Dent, FOA, Dept Clin Surg & Anim Reprod, BR-16050680 Aracatuba, SP, Brazil
dc.descriptionUniv Fed São Paulo, Dept Med, Div Geriatr & Gerontol, Inflammatory Mediators Lab, São Paulo, Brazil
dc.descriptionUniv Estadual Paulista, Sch Dent, FOA, Dept Anim Hlth & Prod, BR-16050680 Aracatuba, SP, Brazil
dc.descriptionUniv Estadual Paulista, Sch Dent, FOA, Dept Clin Surg & Anim Reprod, BR-16050680 Aracatuba, SP, Brazil
dc.format533-540
dc.languageeng
dc.publisherUniversidade Estadual Paulista (Unesp), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)
dc.relationJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.relation1.782
dc.relation0,573
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectIL-6
dc.subjectImmunohistochemistry
dc.subjectLeptospirosis
dc.subjectMice
dc.subjectTNF-α
dc.subjectAnimalia
dc.subjectLeptospira
dc.subjectLeptospira interrogans
dc.subjectLeptospira interrogans serovar Canicola
dc.subjectMus
dc.subjectRattus
dc.titleTNF-alpha and IL-6 immunohistochemistry in rat renal tissue experimentaly infected with Leptospira interrogans serovar Canicola
dc.typeArtigo


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