Serum iron and plasma fibrinogen concentrations as indicators of systemic inflammatory diseases in horses

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBorges, Alexandre Secorun
dc.creatorDivers, Thomas J.
dc.creatorStokol, Tracy
dc.creatorMohammed, O. Hussni
dc.date2014-05-20T15:23:19Z
dc.date2016-10-25T17:57:15Z
dc.date2014-05-20T15:23:19Z
dc.date2016-10-25T17:57:15Z
dc.date2007-05-01
dc.date.accessioned2017-04-05T23:41:28Z
dc.date.available2017-04-05T23:41:28Z
dc.identifierJournal of Veterinary Internal Medicine. Lakewood: Amer Coll Veterinary Internal Medicine, v. 21, n. 3, p. 489-494, 2007.
dc.identifier0891-6640
dc.identifierhttp://hdl.handle.net/11449/34129
dc.identifierhttp://acervodigital.unesp.br/handle/11449/34129
dc.identifier10.1892/0891-6640(2007)21[489:SIAPFC]2.0.CO;2
dc.identifierWOS:000246435200021
dc.identifierhttp://dx.doi.org/10.1892/0891-6640(2007)21[489:SIAPFC]2.0.CO;2
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/878115
dc.descriptionBackground: Detection of systemic inflammation, which is important for proper diagnosis and prompt treatment, can be challenging.Hypothesis: Measurement of plasma iron concentration is a sensitive method for detecting systemic inflammation in horses compared with measurements of plasma Fibrinogen concentration, a traditional marker for inflammation in the horse.Animals: Ninety-seven horses hospitalized with diseases causing systemic inflammation, 22 horses with localized inflammation, and 12 clinically normal horses were included in this study.Methods: A retrospective study was made on hospitalized horses that had both plasma iron and fibrinogen concentrations measured on hospital admission.Results: Plasma iron concentration was lower in horses with systemic inflammation (64 +/- 45 mu g/dL) than the reference interval minimum (105 mu g/dL) and were significantly lower (P = .001) than the value in a group of horses with local inflammation (123 +/- 45 mu g/dL) and in healthy transported horses (143 +/- 29 mu g/dL). Low plasma iron and high fibrinogen concentrations were both sensitive indicators of systemic inflammation in horses with sensitivity of 90 and 82%, respectively. There was a similar correlation between either continued decreases in iron concentration (R-sp of 0.239) or increases in fibrinogen concentration (R-sp of 0.280) during hospitalization and a worse prognosis.Conclusions and Clinical Importance: Measurement of plasma iron concentration better reflected acute inflammation than did fibrinogen concentration.
dc.languageeng
dc.publisherAmer Coll Veterinary Internal Medicine
dc.relationJournal of Veterinary Internal Medicine
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectacute phase reactant protein
dc.subjecthorse
dc.subjectinflammation
dc.titleSerum iron and plasma fibrinogen concentrations as indicators of systemic inflammatory diseases in horses
dc.typeOtro


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